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Brittney Gorman
Biomedical Scientist

Brittney Gorman is a biomedical scientist studying spatial lipidomics involved in human health with EMSL's Rhizosphere Function Integrated Research Platform. Her work includes the integration of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) with other imaging modalities including secondary ion mass spectrometry and fluorescence microscopy. Through her participation in the Kidney Precision Medicine Project, LungMAP, and the Human BioMolecular Atlas Program (HuBMAP), Brittney applies these approaches to investigate the spatial lipidomics and metabolomics in the kidneys and lungs and track changes that occur during disease.

Discipline and Skills

  • MALDI mass spectrometry
  • Secondary ion mass spectrometry
  • Fluorescence microscopy
  • Lipidomics

Education

  • PhD in Biophysics, University of Illinois Urbana-Champaign, 2021
  • BA in Biomedical Physics, Lipscomb University, 2016

Affiliations and Professional Service

  • American Chemical Society, 2012 – present
  • American Society for Mass Spectrometry, 2022 – present
  • Biophysical Society, 2018 – present
  • Females in Mass Spectrometry, 2023 – present

Publications

2025

  • Gorman B.L., C.C. Shafer, N. Ragi, K. Sharma, E.K. Neumann, and C.R. Anderton. 2025. "Imaging and Spatially Resolved Mass Spectrometry Applications in Nephrology." Nature Reviews Nephrology 21, no. 6:399-416. PNNL-SA-206921. doi:10.1038/s41581-025-00946-1
     
  • Vandergrift G.W., M. Velickovic, L.Z. Day, B.L. Gorman, S.M. Williams, B. Shrestha, and C.R. Anderton. 2025. "Untargeted Spatial Metabolomics and Spatial Proteomics on the Same Tissue Section." Analytical Chemistry 97, no. 1:392-400. PNNL-SA-202874. doi:10.1021/acs.analchem.4c04462

2024

  • Gorman B.L., and J.K. Lukowski. 2024. "Spatial metabolomics and lipidomics in kidney disease." Seminars in Nephrology 44, no. 6:Art. No. 151582. PNNL-SA-207560. doi:10.1016/j.semnephrol.2025.151582
     
  • Gorman B.L., M.J. Taylor, L. Tesfay, J.K. Lukowski, P.U. Hegde, J.G. Eder, and K.J. Bloodsworth, et al. 2024. "Applying Multimodal Mass Spectrometry to Image Tumors Undergoing Ferroptosis Following In Vivo Treatment with a Ferroptosis Inducer." Journal of the American Society for Mass Spectrometry 35, no. 1:5-12. PNNL-SA-185527. doi:10.1021/jasms.3c00193
     
  • Kim H., B.L. Gorman, M.J. Taylor, and C.R. Anderton. 2024. "Atomistic Simulations for Investigation of Substrate and Salt Effects on Lipid In-Source Fragmentation in Secondary Ion Mass Spectrometry: A Follow-Up Study." Biointerphases 19, no. 1:Art. No. 011003. PNNL-SA-192467. doi:10.1116/6.0003281

2023

  • Gorman, BL., Torti, S., Torti, F., and Anderton, C.. 2023. "Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications." Biochimica et Biophysica Acta (BBA) - General Subjects.  https://doi.org/10.1016/j.bbagen.2023.130329

2022

  • Brunet, M. Gorman, BL. and Kraft, ML. 2022. "Depth Correction of 3D NanoSIMS Images Shows Intracellular Lipid and Cholesterol Distributions while Capturing the Effects of Differential Sputter Rate." ACS Nano. https://doi.org/10.1021/acsnano.2c05148

2021

  • Gorman, BL., Brunet, M., and Kraft, ML. 2021. "Depth correction of 3D NanoSIMS images using secondary electron pixel intensities." Biointerphases 16, 041005 (2021) https://doi.org/10.1116/6.0001092

2020

  • Patrana-Otero, I., Majumdar, S., Gilchrist, AE., Gorman, BL., Harley, BAC., and Kraft, ML. 2020. "Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform."  Analyst. Issue 21, 2020. https://doi.org/10.1039/D0AN01153C