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David Hoyt

Dr. David Hoyt is a chemist with the Biomolecular Pathways team. Hoyt has over 30 years of experience with research related to nuclear magnetic resonance (NMR) and other forms of spectroscopy. His research focus has been on the structure and dynamics of bio-complexes and metabolite identification via NMR. More recently, his interests have broadened to include biogeochemistry and NMR specialty-probe development projects. Hoyt has co-authored peer-reviewed publications in Nature Microbiology, Nature Communications, Nature Structural Biology, PNAS, Cell, ISME, Molecular Cell, JACS, Biochemistry, and Journal of Magnetic Resonance.

For 10 years Hoyt served in EMSL management and for over 25 years in technical support of the EMSL user program—providing research collaboration in high-field liquids NMR with structural biology and metabolomics applications, as well as in situ chemistry projects.

Hoyt was responsible to site and develop ~$12 million in new American Reinvestment and Recovery Act funded magnetic resonance systems between June 2009 and November 2011. He has also served as project manager of several recent procurements for PNNL. From 2002 to present he worked to site and develop over $40 million in NMR and electron paramagnetic resonance equipment with EMSL operations. This work included enhancements to in situ controlled-environment NMR and metabolomics capabilities. His leadership on the R&D team for high temperature and high-pressure NMR rotor capability development for in situ measurements of mixed-phased chemistry and biologics has recently led to licensing by Revolution NMR LLC (Fort Collins, CO). His present interests now include advancing PNNL and EMSL science through further work developing and participating in research and R&D of integrated capabilities related to biological, environmental, and molecular-interface contexts.

Research Interests

  • NMR
  • Metabolomics
  • NMR technology development for controlled sample environments to aid in situ measurements
  • Supercritical Fluid/Mineral/Microbe Interactions
  • Bio-oils and Biofuels
  • Structural Basis for Protein-Protein Interactions
  • Other Spectroscopies: CD, Fluorescence


  • PhD in Biochemistry, University of Texas Southwestern Medical Center, 1990
  • MA in Biochemistry, University of Delaware, 1987
  • BS in Chemistry, Millersville University, 1983

Awards and Recognition

Affiliations and Professional Service

  • Past Reviewer, Small Business Innovation Research and Small Business Technology Transfer Program, Office of Science, U.S. Department of Energy
  • Past Reviewer, Chemical Research Instrumentation and Facility, National Science Foundation
  • Past Reviewer, Natural Sciences and Engineering Research Council of Canada
  • Past Reviewer, Computing in Science & Engineering
  • American Chemical Society
  • American Association for the Advancement of Science
  • American Geophysical Union
  • American Society for Microbiology
  • Metabolomics Society


  • ED Walter, JA Sears, HS Mehta, DW Hoyt. 2020. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” US Patent No. 10,550,889.
  • JZ Hu, JA Sears, DW Hoyt, HS Mehta, CHF Peden. 2015. “Magic Angle Spinning Nuclear Magnetic Resonance Apparatus and Process for High-Resolution In Situ Investigations.” U.S. Patent No. 9,194,920.
  • DW Hoyt, JA. Sears, RVF Turcu, KM Rosso, and JZ Hu. 2014. “Devices and Process for High-Pressure Magic Angle Spinning Nuclear Magnetic Resonance.” U.S. Patent No. 8,692,548.
  • JZ Hu, JA Sears, DW Hoyt, and RA Wind. 2009. “Discrete Magic Angle Turning System, Apparatus and Process for In Situ Magnetic Resonance Spectroscopy and Imaging.” U.S. Patent No. 7,535,224.  
  • ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed June 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance.” German Patent Pending – DE201710112768  (IPID-30618-E-DE).
  • ED Walter, JA Sears, HS Mehta, DW Hoyt. Filed July 1, 2017. “Snap-in Bushings and Process for High-Pressure and/or High Temperature Magic Angle Spinning Nuclear Magnetic Resonance” Japan Patent Pending - JP2017144364A (IPID-30618-E-JP).



Bowers G.M., E.D. Walter, S.D. Burton, K.C. Schwarz, D.W. Hoyt, and R.J. Kirkpatrick. 2020. "Probing Pore Size and Connectivity in Porous Silicas Using 13C MAS NMR Spectroscopy of Supercritical Methane." Journal of Physical Chemistry C 124, no. 21:11536-11543. PNNL-SA-153506. doi:10.1021/acs.jpcc.0c02718

Ilhan Z.E., J.K. DiBaise, S.E. Dautel, N.G. Isern, Y. Kim, D.W. Hoyt, and A.A. Schepmoes, et al. 2020. "Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery." NPJ Biofilms and Microbiomes 6, no. 1:Article No. 12. PNNL-SA-133750. doi:10.1038/s41522-020-0122-5

Khare S., G.M. Deloid, R.M. Molina, K. Gokulan, S.P. Couvillion, K.J. Bloodsworth, and E.K. Eder, et al. 2020. "Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats." NanoImpact 18. PNNL-SA-149247. doi:10.1016/j.impact.2020.100216

Smercina, D.N.; Bowsher, A.W.; Evans, S.E.; Friesen, M.L.; Eder, E.K.; Hoyt, D.W.; Tiemann, L.K. 2020. “Switchgrass Rhizosphere Metabolite Chemistry Driven by Nitrogen Availability.” Phytobiomes Journal. PNNL-SA-152631  DOI: 10.1094/PBIOMES-09-19-0055-FI 


Booker A.E., D.W. Hoyt, T. Meulia, E.K. Eder, C.D. Nicora, S.O. Purvine, and R. Daly, et al. 2019. "Deep-Subsurface Pressure Stimulates Metabolic Plasticity in Shale-Colonizing Halanaerobium spp." Applied and Environmental Microbiology 85, no. 12:e00018-19. PNNL-SA-144542. doi:10.1128/AEM.00018-19

Bowers G.M., H.T. Schaef, Q. Miller, E.D. Walter, S.D. Burton, D.W. Hoyt, and J.A. Horner, et al. 2019. "13C Nuclear Magnetic Resonance Spectroscopy of Methane and Carbon Dioxide in a Natural Shale." ACS Earth and Space Chemistry 3, no. 3:324-328. PNNL-SA-140683. doi:10.1021/acsearthspacechem.8b00214

Bowers G.M., J.S. Loring, E.D. Walter, S.D. Burton, M.E. Bowden, D.W. Hoyt, and B.W. Arey, et al. 2019. "Influence of Smectite Structure and Hydration on Supercritical Methane Binding and Dynamics in Smectite Pores." Journal of Physical Chemistry C 123, no. 48:29231-29244. PNNL-SA-146425. doi:10.1021/acs.jpcc.9b08875

Chamas A., L. Qi, H.S. Mehta, J.A. Sears, S.L. Scott, E.D. Walter, and D.W. Hoyt. 2019. "High Temperature/Pressure MAS-NMR for the Study of Dynamic Processes in Mixed Phase Systems." Magnetic Resonance Imaging 56. PNNL-SA-138048. doi:10.1016/j.mri.2018.09.026

Daly R., S. Roux, M. Borton, D.M. Morgan, M.D. Johnston, A.E. Booker, and D.W. Hoyt, et al. 2019. "Viruses control dominant bacteria colonizing the terrestrial deep biosphere after hydraulic fracturing." Nature Microbiology 4, no. 2:352-361. PNNL-SA-134613. doi:10.1038/s41564-018-0312-6

Evans M.V., G. Getzinger, J.L. Luek, A.J. Hanson, M.C. McLaughlin, J. Blotevogel, and S. Welch, Nicora, C.D.; Purvine, S.O.; Xu, C.; Cole, D.R.; Darrah, T.H.; Hoyt, D.W.; Metz, T.O.; Ferguson, P.L.; Lipton, M.S.; Wilkins, M.J.; Mouser, P.J. 2019. "In situ transformation of ethoxylate and glycol surfactants by shale-colonizing microorganisms during hydraulic fracturing." The ISME Journal 13, no. 11:2690-2700. PNNL-SA-141428. doi:10.1038/s41396-019-0466-0

Fudyma J.D., J.E. Lyon, R. Aminitabrizi, H. Gieschen, R.K. Chu, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites." Plant Direct 3, no. 11:Article No. e00179. PNNL-SA-146621. doi:10.1002/pld3.179

Lynch L.M., M. Machmuller, C.M. Boot, T.P. Covino, C.D. Rithner, F. Cotrufo, and D.W. Hoyt, et al. 2019. "Dissolved organic matter chemistry and transport along an Arctic Tundra Hillslope." Global Biogeochemical Cycles 33, no. 1:47-62. PNNL-SA-136691. doi:10.1029/2018GB006030

Mehta H.S., Y. Chen, J.A. Sears, E.D. Walter, M. Campos, J. Kothandaraman, and D.J. Heldebrant, et al. 2019. "A Novel High-Temperature MAS Probe with Optimized Temperature Gradient across Sample Rotor for In-situ Monitoring of High-Temperature High-Pressure Chemical Reactions." Solid State Nuclear Magnetic Resonance 102. PNNL-SA-143153. doi:10.1016/j.ssnmr.2019.06.003

Miller Q., D.A. Dixon, S.D. Burton, E.D. Walter, D.W. Hoyt, A.S. Mcneill, and J. Moon, et al. 2019. "Surface-Catalyzed Oxygen Exchange during Mineral Carbonation in Nanoscale Water Films." Journal of Physical Chemistry C 123, no. 20:12871-12885. PNNL-SA-141756. doi:10.1021/acs.jpcc.9b02215

Narrowe, A.B.; Borton, M.A.; Hoyt, D.W.; Smith, G.J.; Daly, R.A.; Angle, J.A.; Eder, E.K.; Wong, Q.R.; Wolfe, R.A.; Pappas, A.; Bohrer, G.; Miller, C.S.; Wrighton, K.C. 2019. “Uncovering the diversity and activity of methylotrophic methanogens in freshwater wetland soils.” mSystems 4(6) e00320-19. PNNL-SA-152910 DOI: 10.1128/mSystems.00320-19

Qi L., A. Chamas, Z.R. Jones, E.D. Walter, D.W. Hoyt, N.M. Washton, and S.L. Scott. 2019. "Unraveling the Dynamic Network in the Reactions of an Alkyl Aryl Ether Catalyzed by Ni/y-Al2O3 in 2-Propanol." Journal of the American Chemical Society 141, no. 43:17370-17381. PNNL-SA-148402. doi:10.1021/jacs.9b09071

Sharon G., N.J. Cruz, D. Kang, M. Gandal, B. Wang, Y. Kim, and E.M. Zink, et al. 2019. "Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice." Cell 177, no. 6:1600-1618. PNNL-SA-131563. doi:10.1016/j.cell.2019.05.004

Stavila V., M. Foster, J.W. Brown, R.W. Davis, J. Edgington, A.I. Benin, and R.A. Zarkesh, et al. 2019. "IRMOF-74(n)-Mg: a novel catalyst series for hydrogen activation and hydrogenolysis of C-O bonds." Chemical Science 10, no. 42:9880-9892. PNNL-SA-147308. doi:10.1039/C9SC01018A

Tfaily M., R.M. Wilson, H.M. Brewer, R.K. Chu, H.M. Heyman, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Single-throughput complementary high-resolution analytical techniques for characterizing complex natural organic matter mixtures." Journal of Visualized Experiments. PNNL-SA-138197. doi:10.3791/59035

Wang, G; Zhao, Z.; Ke, J.; Engel, Y.; Shi, YM.; Zhang, Z., Bingol, K; Robinson, D. Evans, R.; Miyamoto, Y.; Cheng, K.; Bowen, B.; Louie, K.; Kosina, S.; de Radd, M.; Silva, L.; Luhrs, A.; Lubbe, A.; Hoyt, D W..; Francavilla, C.; Ohtani, H.; Deutsch, S.; Washton, N. M.; Rubin, E.M.; Mouncey, N.; Visel, A.; Cheng, J.F.; Northen, T.; Bode, H.; Yoshikuni, Y. 2019. “Chassis-Independent Recombinase-Assisted Genome Engineering Enables Rapid Activation of  Biosynthetic Gene Clusters.” Nature Microbiology 2019 4, 2498-2510. PNNL-SA- 133313  DOI: 10.1038/s41564-019-0573-8 


Borton M., D.W. Hoyt, S. Roux, R. Daly, S. Welch, C.D. Nicora, and S.O. Purvine, et al. 2018. "Coupled laboratory and field investigations resolve microbial interactions that underpin persistence in hydraulically fractured shales." Proceedings of the National Academy of Sciences of the United States of America 115, no. 28:E6585-E6594. PNNL-SA-134972. doi:10.1073/pnas.1800155115

Borton, M.A.; Daly, R.A.; O’Banion, B.O.; Hoyt, D.W.; Marcus, D.N.; Welch, S.; Hastings, S.; Meulia, T.; Wolfe, R.A.; Booker, A.E.; Sharma, S.; Cole, D.R.; Wunch, K.; Moore, J.D.; Thomas, D.; Wilkins, M.J.; Wrighton, K.C. 2018. “Comparative genomics and physiology of the genus Methanohalophilus, a prevalent methanogen in hydraulically fractured shale” Environmental Microbiology 20(12), 4596-4611. PNNL-SA-138432  DOI: 10.1111/1462-2920.14467 

Boiteau, R.M.; Hoyt, DW; Nicora, C.D.; Kinmonth-Schultz, H.A.; Ward, J.K.; Bingol, K. 2018. “Structure Elucidation of Unknown Metabolites in Metabolomics by Combined NMR and MS/MS Prediction.” Metabolites 2018, 8(1), 8; PNNL-SA-132082 doi:10.3390/metabo8010008. --- Journal Cover -

Kang D., Z.E. Ilhan, N.G. Isern, D.W. Hoyt, D.P. Howsmon, M. Shaffer, and C. Lozupone, et al. 2018. "Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders." Anaerobe 49. PNNL-SA-127135. doi:10.1016/j.anaerobe.2017.12.007

Kothandaraman J., R.A. Dagle, V. Dagle, S.D. Davidson, E.D. Walter, S.D. Burton, and D.W. Hoyt, et al. 2018. "Condensed-Phase Low Temperature Heterogeneous Hydrogenation of CO2 to Methanol." Catalysis Science & Technology 8, no. 19:5098-5103. PNNL-SA-133245. doi:10.1039/C8CY00997J

Roy Chowdhury T., L.M. Bramer, D.W. Hoyt, Y. Kim, T.O. Metz, L. McCue, and H.L. Diefenderfer, et al. 2018. "Temporal dynamics of CO2 and CH4 loss potentials in response to rapid hydrological shifts in tidal freshwater wetland soils." Ecological Engineering 114. PNNL-SA-123359. doi:10.1016/j.ecoleng.2017.06.041

Solden, L.M.; Naas AE; Roux, S.; Daly, R.A.; Collins, W.B.; Nicora, C.D.; Purvine, S.O.; Hoyt, D.W.; Schuckel J.; Joergensen, B.; Willats W.; Spalinger D.E.; Firkins JL; Lipton M.S.; Sullivan M.B.; Pope P.B.; Wrighton, K.C. 2018. “Interspecies cross-feedings orchestrate carbon degradation in the rumen ecosystem.” Nature Microbiology 3, 1274–1284. PNNL-SA-131180 

Walter E.D., L. Qi, A. Chamas, H.S. Mehta, J.A. Sears, S.L. Scott, and D.W. Hoyt. 2018. "Operando MAS NMR Reaction Studies at High Temperatures and Pressures." Journal of Physical Chemistry C 122, no. 15:8209-8215. PNNL-SA-130852. doi:10.1021/acs.jpcc.7b11442 

--  Journal Cover – 04/19/2018  PNNL-SA-130852


Angle J., T.A. Morin, L. Solden, A.B. Narrowe, G.J. Smith, M. Borton, and C. Rey-Sanchez, et al. 2017. "Methanogenesis in oxygenated soils is a substantial fraction of wetland methane emissions." Nature Communications 8. PNNL-SA-125731. doi:10.1038/s41467-017-01753-4

Booker A.E., M. Borton, R. Daly, S. Welch, C.D. Nicora, D.W. Hoyt, and T. Wilson, et al. 2017. "Sulfide Generation by Dominant Halanaerobium Microorganisms in Hydraulically Fractured Shales." mSphere 2. PNNL-SA-128950. doi:10.1128/mSphereDirect.00257-17

Bowers G.M., H.T. Schaef, J.S. Loring, D.W. Hoyt, S.D. Burton, E.D. Walter, and R.J. Kirkpatrick. 2017. "Role of Cations in CO2 Adsorption, Dynamics, and Hydration in Smectite Clays Under in situ Supercritical CO2 Conditions." Journal of Physical Chemistry C 121, no. 1:577-592. PNNL-SA-122523. doi:10.1021/acs.jpcc.6b11542

Dalcin Martins P., D.W. Hoyt, S. Bansal, C. Mills, M.M. Tfaily, B.A. Tangen, and R.G. Fincchiaro, et al. 2017. "Abundant carbon substrates drive extremely high sulfate reduction rates and methane fluxes in Prairie Pothole Wetlands." Global Change Biology 23, no. 8:3107-3120. PNNL-SA-120033. doi:10.1111/gcb.13633

Ilhan Z.E., J.K. DiBaise, N.G. Isern, D.W. Hoyt, A.K. Marcus, D. Kang, and M. Crowell, et al. 2017. "Distinctive microbiomes and metabolites linked with weight loss after gastric bypass, but not gastric banding." The ISME Journal 11, no. 9:2047-2058. PNNL-SA-119449. doi:10.1038/ismej.2017.71

Jaegers, N.R.; Hu MY, Hoyt DW, Wang Y, and Hu JZ. 2017 "Development and application of in-situ high-temperature, high-pressure magic angle spinning NMR" Modern Magnetic Resonance, 2nd Edition. Pp.1-19. Editor: Graham A. Webb.   Book Chapter. PNNL-SA-127762 DOI: 10.1007/978-3-319-28275-6_93-1

Ok S., D.W. Hoyt, A. Andersen, J. Sheets, S. Welch, D.R. Cole, and K.T. Mueller, et al. 2017. "Surface Interactions and Confinement of Methane: A High Pressure Magic Angle Spinning NMR and Computational Chemistry Study." Langmuir 33, no. 6:1359-1367. PNNL-SA-123185. doi:10.1021/acs.langmuir.6b03590

Qi L., R. Alamillo, W.A. Elliott, A. Andersen, D.W. Hoyt, E.D. Walter, and K. Han, et al. 2017. "Operando solid-state NMR observations of solvent-mediated adsorption-reaction of carbohydrates in zeolites." ACS Catalysis 7, no. 5:3489-3500. PNNL-SA-119548. doi:10.1021/acscatal.7b01045

Schaef H.T., N. Loganathan, G.M. Bowers, R.J. Kirkpatrick, A.O. Yazaydin, S.D. Burton, and D.W. Hoyt, et al. 2017. "Tipping Point for Expansion of Layered Aluminosilicates in Weakly Polar Solvents: Supercritical CO2." ACS Applied Materials & Interfaces 9, no. 42:36783-36791. PNNL-SA-127664. doi:10.1021/acsami.7b10590

Solden L., D.W. Hoyt, W.B. Collins, J.E. Plank, R. Daly, E. Hildebrand, and T.J. Beavers, et al. 2017. "New roles in hemicellulosic sugar fermentation for the uncultivated Bacteroidetes family BS11." The ISME Journal 11, no. 3:691-703. PNNL-SA-115562. doi:10.1038/ismej.2016.150

White R.A., A. Rivas-Ubach, M.I. Borkum, M. Koberl, A. Bilbao Pena, S.M. Colby, and D.W. Hoyt, et al. 2017. "The state of rhizospheric science in the era of multi-omics: A practical guide to omics technologies." Rhizosphere 3, no. 2:212-221. PNNL-SA-124859. doi:10.1016/j.rhisph.2017.05.003


Daly R., M.A. Borton, M.J. Wilkins, D.W. Hoyt, D.J. Kountz, R. Wolfe, and S. Welch, et al. 2016. "Microbial metabolisms in a new 2.5 km deep ecosystem created by hydraulic fracturing in shales." Nature Microbiology 1, no. 10:Article No. 16146. PNNL-SA-115522. doi:10.1038/nmicrobiol.2016.146

Walker L.R., D.W. Hoyt, S. Walker, J.K. Ward, C.D. Nicora, and A.K. Bingol. 2016. "Unambiguous Metabolite Identification in High-throughput Metabolomics by Hybrid 1D 1H NMR/ESI MS1 Approach." Magnetic Resonance in Chemistry 54, no. 12:998-1003. PNNL-SA-117020. doi:10.1002/mrc.4503


Jung H., K. Carroll, S. Kabilan, D.J. Heldebrant, D.W. Hoyt, L. Zhong, and T. Varga, et al. 2015. "Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids as a Greener Alternative to Support Geothermal and Fossil Energy Production." Green Chemistry 17, no. 5:2799-2812. PNNL-SA-106027. doi:10.1039/c4gc01917b

Jung, HB, H Shao, DJ Heldebrant, S Niraj, T Varga, D Hoyt, S Kabilan, L Zhong, A Bonneville, W Um, KC Carroll, J Holladay, and CA Fernandez. 2015. “Stimuli-Responsive/Rheoreversible Hydraulic Fracturing Fluids for Enhanced Geothermal Systems” Proceedings World Geothermal Congress, 19- 25.


Bowers G.M., D.W. Hoyt, S.D. Burton, B.O. Ferguson, T. Varga, and R.J. Kirkpatrick. 2014. "In Situ 13C and 23Na Magic Angle Spinning NMR Investigation of Supercritical CO2 Incorporation in Smectite-Natural Organic Matter Composites." Journal of Physical Chemistry C 118, no. 7:3564-3573. PNNL-SA-99489. doi:10.1021/jp410535d

Wilkins M.J., D.W. Hoyt, M.J. Marshall, P.A. Alderson, A.E. Plymale, L.M. Markillie, and A.E. Tucker, et al. 2014. "CO2 exposure at pressure impacts metabolism and stress responses in the model sulfate-reducing bacterium Desulfovibrio vulgaris strain Hildenborough." Frontiers in Microbiology 5. PNNL-SA-103791. doi:10.3389/fmicb.2014.00507


Feng J., J.Z. Hu, S.D. Burton, and D.W. Hoyt. 2013. "High Resolution Magic Angle Spinning 1H-NMR Metabolic Profiling of Nanoliter Biological Tissues at High Magnetic Field." Chinese Journal of Magnetic Resonance 30, no. 1:1-11. PNNL-SA-89007.

Loring J.S., H.T. Schaef, C.J. Thompson, R.V. Turcu, Q.R. Miller, J. Chen, and J.Z. Hu, et al. 2013. "Clay hydration/dehydration in dry to water-saturated supercritical CO2: Implications for caprock integrity." Energy Procedia 37. PNNL-SA-91508. doi:10.1016/j.egypro.2013.06.463

Miller Q., C.J. Thompson, J.S. Loring, C.F. Windisch, M.E. Bowden, D.W. Hoyt, and J.Z. Hu, et al. 2013. "Insights into Silicate Carbonation Processes in Water-Bearing Supercritical CO2 Fluids." International Journal of Greenhouse Gas Control 15. PNNL-SA-89916. doi:10.1016/j.ijggc.2013.02.005

Turcu R.V., D.W. Hoyt, K.M. Rosso, J.A. Sears, J.S. Loring, A.R. Felmy, and J.Z. Hu. 2013. "Rotor Design for High Pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 226. PNNL-SA-88703. doi:10.1016/j.jmr.2012.08.009


Hu J.Z., J.A. Sears, H.S. Mehta, J.J. Ford, J. Kwak, K. Zhu, and Y. Wang, et al. 2012. "A Large Sample Volume Magic Angle Spinning Nuclear Magnetic Resonance Probe for In-Situ Investigations with Constant Flow of Reactants." Physical Chemistry Chemical Physics. PCCP 14, no. 7:2137-2143. PNNL-SA-82533. doi:10.1039/c1cp22692d

Loring J.S., H.T. Schaef, R.V. Turcu, C.J. Thompson, Q. Miller, P.F. Martin, and J.Z. Hu, et al. 2012. "In Situ Molecular Spectroscopic Evidence for CO2 Intercalation into Montmorillonite in Supercritical Carbon Dioxide." Langmuir 28, no. 18:7125-7128. PNNL-SA-86500. doi:10.1021/la301136w


Ahring B.K., N.S. Baliga, J.R. Frederickson, S. Kaplan, H.B. Pakrasi, J.G. Pounds, and I. shah, et al. 2011. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP). PNNL-20717. Richland, WA: Pacific Northwest National Laboratory. Biological Interactions and Dynamics Science Theme Advisory Panel (BID-STAP)

Brown G.E., A. Chaka, D.K. Shuh, E.E. Roden, C.J. Werth, N.J. Hess, and A.R. Felmy, et al. 2011. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting. PNNL-20601. Richland, WA: Pacific Northwest National Laboratory. EMSL Geochemistry, Biogeochemistry and Subsurface Science-Science Theme Advisory Panel Meeting

Campbell C.T., A.K. Datye, G.A. Henkelman, R.F. Lobo, W.F. Schneider, L.D. Spicer, and W.T. Tysoe, et al. 2011. EMSL and Institute for Integrated Catalysis (IIC) Catalysis Workshop. PNNL-20426. Richland, WA: Pacific Northwest National Laboratory. EMSL and Institute for Integrated Catalysis (IIC) Catalysis Workshop

Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, A.R. Felmy, and J.Z. Hu. 2011. "High-pressure Magic Angle Spinning Nuclear Magnetic Resonance." Journal of Magnetic Resonance 212, no. 2:378-385. PNNL-SA-80681. doi:10.1016/j.jmr.2011.07.019

Hoyt D.W., R.V. Turcu, J.A. Sears, K.M. Rosso, S.D. Burton, J. Kwak, and A.R. Felmy, et al. 2011. "IN SITU MAGIC ANGLE SPINNING NMR FOR STUDYING GEOLOGICAL CO(2) SEQUESTRATION." In 241st National Meeting and Exposition of the American Chemical Society, March 27-31, 2011, Anaheim, California, 241, 245-Fuel. Washington Dc:American Chemical Society. PNNL-SA-77039.

Kwak J., J.Z. Hu, R.V. Turcu, K.M. Rosso, E.S. Ilton, C.M. Wang, and J.A. Sears, et al. 2011. "The Role of H2O in the Carbonation of Forsterite in Supercritical CO2." International Journal of Greenhouse Gas Control 5, no. 4:1081-1092. PNNL-SA-76665. doi:10.1016/j.ijggc.2011.05.013

Teklemichael S.T., W. Oo, M. Matthew, E.D. Walter, and D.W. Hoyt. 2011. "Acceptors in ZnO nanocrystals." Applied Physics Letters 98, no. 23:Article No. 232112. PNNL-SA-79839. doi:10.1063/1.3598411

White M.D., B.P. McGrail, H.T. Schaef, J.Z. Hu, D.W. Hoyt, A.R. Felmy, and K.M. Rosso, et al. 2011. "Multiphase Sequestration Geochemistry: Model for Mineral Carbonation." Energy Procedia 4. PNNL-SA-74658. doi:10.1016/j.egypro.2011.02.472


Kwak J., J.Z. Hu, D.W. Hoyt, J.A. Sears, C.M. Wang, K.M. Rosso, and A.R. Felmy. 2010. "Metal Carbonation of Forsterite in Supercritical CO2 and H2O Using Solid State 29Si, 13C NMR Spectroscop." Journal of Physical Chemistry C 114, no. 9:4126 - 4134. PNNL-SA-68897. doi:10.1021/jp1001308


Chen B., X. Ren, T. Neville, W. Jerome, D.W. Hoyt, D.L. Sparks, and G. Ren, et al. 2009. "Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes." Protein Science 18, no. 5:921-935. PNNL-SA-56783. doi:10.1002/pro.101

Hu J.Z., J.A. Sears, J. Kwak, D.W. Hoyt, Y. Wang, and C.H. Peden. 2009. "An Isotropic Chemical Shift-Chemical Shift Anisotropic Correlation Experiment Using Discrete Magic Angle Turning." Journal of Magnetic Resonance 198, no. 1:105-110. PNNL-SA-63634.


Briknarova K., X. Zhou, A.C. Satterthwait, D.W. Hoyt, K.R. Ely, S. Huang, and S. Huang. 2008. "Structural Studies of the SET Domain from RIZ1 Tumor Suppressor." Biochemical and Biophysical Research Communications 366, no. 3:807-813. PNNL-SA-56117. doi:10.1016/j.bbrc.2007.12.034


Ren X., Y. Yang, T. Neville, T. Neville, D.W. Hoyt, D.L. Sparks, and J. Wang. 2007. "A complete backbone spectral assignment of human apolipoprotein AI on a 38 kDa preßHDL (Lp1-AI) particle." Biomolecular NMR Assignments 1, no. 1:69-71. PNNL-SA-53926. doi:10.1007/s12104-007-9020-5

Smirnov S., N.G. Isern, Z.G. Jiang, D.W. Hoyt, and C.J. Mcknight. 2007. "The Isolated Sixth Gelsolin Repeat and Headpiece Domain of Villin Bundle F-Actin in the Presence of Calcium and Are Linked by a 40-Residue Unstructured Sequence." Biochemistry 46, no. 25:7488-7496. PNNL-SA-55624. doi:10.1021/bi700110v

Yang Y., D.W. Hoyt, and J. Wang. 2007. "A Complete NMR Spectral Assignment of the Lipid-free Mouse Apolipoprotein A-I (ApoAI) C-terminal Truncation Mutant, ApoAI(1-216)." Biomolecular NMR Assignments 1, no. 1:109-111. PNNL-SA-53927. doi:10.1007/s12104-007-9031-2


Brzovic P.S., A.V. Lissounov, D. Christensen, D.W. Hoyt, and R.E. Klevit. 2006. "A UbcH5/Ubiquitin Noncovalent Complex is Required for Processive BRCA1-Directed Ubiquitination." Molecular Cell 21, no. 6:873-880. PNNL-SA-48810. DOI:  10.1016/j.molcel.2006.02.008


Briknarova K., F. Nasertorabi, M.L. Havert, E. Eggleston, D.W. Hoyt, C. Li, and A.J. Olson, et al. 2005. "The Serine-rich Domain from Crk-associated Substrate (p130Cas) is a Four-helix Bundle." Journal of Biological Chemistry 280, no. 23:21908-21914. PNNL-SA-45324. doi: 10.1074/jbc.M501258200

Xu C., A. Sivashanmugam, D.W. Hoyt, and J. Wang. 2005. "A Complete Backbone Assignment of the Apolipoprotein E LDL Receptor Binding Domain [Letter to the Editor]." Journal of Biomolecular NMR 32, no. 2:177. PNNL-SA-44749. doi:10.1007/s10858-005-6729-2


Hoyt D.W., S.D. Burton, M.R. Peterson, J.D. Myers, and G. Chin. 2004. "Expanding Your Laboratory by Accessing Collaboratory Resources." Analytical and Bioanalytical Chemistry 378, no. 6:1408-1410. PNNL-SA-39416. DOI: 10.1007/s00216-003-2428-6 


Briknarova K., M. Akermann, D.W. Hoyt, E. Ruoslahti, and K.R. Ely. 2003. "Anastellin, an FN3 Fragment with Fibronectin Polymerization Activity, Resembles Amyloid Fibril Precursors." Journal of Molecular Biology 332, no. 1:205-215. PNNL-SA-38930. DOI: 10.1016/S0022-2836(03)00890-8

Kreishman-Detrick M., C. Egile, D.W. Hoyt, J.J. Ford, R. Li, and M.K. Rosen. 2003. "NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex." Biochemistry 42, no. 28:8579-8586. PNNL-SA-39415. DOI: 10.1021/bi034536j

Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson Iii. 2003. "Investigation of the role of the histidine-aspartate pair in the human exonuclease III-like abasic endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-40864. DOI: 10.1016/S0022-2836(03)00382-6

Lowry D.F., D.W. Hoyt, F.A. Khazi, J.R. Bagu, A.G. Lindsey, and D.M. Wilson. 2003. "Investigation of the Role of the Histidine-Aspartate Pair in the Human Exonuclease III-like Abasic Endonuclease, Ape1." Journal of Molecular Biology 329, no. 2:311-322. PNNL-SA-36499. DOI: 10.1016/S0022-2836(03)00382-6


Briknarova K., S. Takayama, S. Homma, K. Baker, E. Cabezas, D.W. Hoyt, and Z. Li, et al. 2002. "BAG4/SODD Protein Contains a Short BAG Domain." Journal of Biological Chemistry 277, no. 34:31172-31178. PNNL-SA-36503. doi: 10.1074/jbc.M202792200

Chin G., J.D. Myers, and D.W. Hoyt. 2002. "Social Networks in the Virtual Science Laboratory." Communications of the ACM 45, no. 8:87-92. PNNL-SA-35242. doi>10.1145/545151.545156

McInnes, E.; DW Hoyt, M O'Connor-McCourt, and BD Sykes.  2002. “Characterization of Transforming Growth Factor-a Binding to Epidermal Growth Factor Receptor Through NMR Structure Determination and NOE Analysis Methods.” Peptides Frontier of Peptide Science: Proceedings of the Fifteenth American Peptide Symposium, Tam and Kaumaya (Ed.), Springer Netherlands. DOI:10.1007/0-306-46862-X_158


Briknarova K., S. Takayama, L. Brive, M.L. Havert, D.A. Knee, J. Velasco, and S. Homma, et al. 2001. "Structural Analysis of BAG1 Cochaperone and Its Interactions with Hsc70 Heat Shock Protein." Nature Structural Biology 8, no. 4:349-352. PNNL-SA-33922. doi:10.1038/86236

Bryant P.L., C. Harwell, A.A. Mrse, E.F. Emery, Z. Gan, T. Caldwell, and A.P. Reyes, et al. 2001. "Structural Characterization of MAO and Related Aluminum Complexes. 1. Solid-State 27 Al NMR with Comparison to EFG Tensors from ab Initio Molecular Orbital Calculations." Journal of the American Chemical Society 123. PNNL-SA-33924. DOI: 10.1021/ja011092a

Brzovic P.S., P. Rajagopal, D.W. Hoyt, M. King, and R.E. Klevit. 2001. "Structure of a BRCA1/BARD1 Complex: a Heterodimeric RING-RING Interaction." Nature Structural Biology 8, no. 10:833-837. PNNL-SA-34960. doi:10.1038/nsb1001-833


Liu K., H.S. Cho, D.W. Hoyt, T.N. Nguyen, P. Olds, J.W. Kelly, and D. Wemmer. 2000. "Deuterium-proton Exchange on the Native Wild-type Transthyretin Tetramer Identifies the Stable Core of the Individual Subunits and Indicates Mobility at the Subunit Interface." Journal of Molecular Biology 303, no. 4:555-565. PNNL-SA-33925. DOI: 10.1006/jmbi.2000.4164


Buchko, G.W.; A Rozek, DW Hoyt, RJ Cushley, and MA Kennedy. 1998. “The Use of Sodium Dodecyl Sulfate to Model the Apolipoprotein Environment Evidence for Peptide-SDS Complexes Using Pulsed-field Gradient NMR Spectroscopy.” Biochimica et Biophysica Acta.  1392:101-108. DOI: 10.1016/S0005-2760(98)00028-9