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Kevin Zemaitis
Post-Doctorate Research Associate

Kevin Zemaitis is an analytical chemist in Research Technology Development and Deployment team at the Environmental Molecular Sciences Laboratory. He is a bioanalytical chemist focused on developing and deploying spatial-omics methods on Fourier transform mass spectrometry (FTMS) platforms, refining ambient ionization sources, and developing the next generation of hybrid FTMS instruments. Currently, his research spans multiple fields of -omics, including on-tissue chemical derivatization method development for spatial metabolomics, applications of ultrahigh mass resolving power for spatial lipidomics, and developing spatial proteomics workflows with advanced dissociation methods within programmatically funded projects on microbial, plant, and mammalian samples.

Research Interests

  • Fourier transform mass spectrometry
  • Instrument and source development
  • Spatial multiomics

Education

  • PhD in analytical chemistry, SUNY at Buffalo, 2021 
  • BA in chemistry and psychology, SUNY at Buffalo, 2016 

Affiliations and Professional Service

  • Review Editor for Analytical Chemistry, Frontiers in Chemistry, 2023–2025
  • Member, US Human Proteome Organization, 2021–present
  • Member, Society for Applied Spectroscopy, 2020–present
  • Member, Metabolomics Association of North America, 2019–present
  • Member, American Society of Mass Spectrometry, 2018–present
  • Member, American Chemical Society, 2016–present

Publications

2023

Zemaitis K.J. et al. 2023. “Expanded molecular imaging of phytocompounds by mass spectrometry using novel on-tissue chemical derivatization.” Analytical Chemistry 95 (34): 12701. https://doi.org/10.1021/acs.analchem.3c01345

Degnan D.J., Zemaitis K.J., Lewis L.A., McCue L.A., Bramer L.M., Fulcher J.M., Veličković D., Paša-Tolić L., Zhou M. 2023. “IsoMatchMS: Open-Source Software for Automated Annotation and Visualization of High Resolution MALDI Spectra.” Journal of the American Society for Mass Spectrometry.  https://doi.org/10.1021/jasms.3c00180

Jain S.et al. 2023. “Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP).” Nature Cell Biology. 25: 1089. https://doi.org/10.1038/s41556-023-01194-w

Vandergrift G.W. et al. 2023. “Experimental assessment of lipid complexity using multimodal 21T FTICR mass spectrometry imaging.” Analytical Chemistry.  95 (29): 10921. https://doi.org/10.1021/acs.analchem.3c00518

Pires A.P.P. et al. 2023. "Comparison of the Chemical Composition of Liquids from the Pyrolysis and Hydrothermal Liquefaction of Lignocellulosic Materials." Energy & Fuels 37 (10): 7221. https://doi.org/10.1021/acs.energyfuels.2c03239

Liao Y.C. et al. 2023. “Spatially resolved top-down proteomics of tissue sections based on a microfluidic nanodroplet sample preparation platform." Molecular & Cellular Proteomics. 22 (2): e100491. https://doi.org/10.1016/j.mcpro.2022.100491

Vandergrift G.W. et al. 2023. "Are phosphatidic acids ubiquitous in mammalian tissues or overemphasized in mass spectrometry imaging applications?” Analysis & Sensing. e202200112. https://doi.org/10.1002/anse.202200112):

Zemaitis K.J. et al. 2023.“193 nm ultraviolet photodissociation for the characterization of singly charged proteoforms generated by MALDI.” Journal of the American Society for Mass Spectrometry. 34 (2): 328. https://doi.org/10.1021/jasms.2c00302

2022

Zhou M. et al. 2022. “Understanding Proteoform Biology of Symbiosis in Soybean Root Nodules by Top-Down Proteomics.” Frontiers in Analytical Chemistry 2: 1012707. https://doi.org/10.3389/frans.2022.1012707

Zemaitis K.J. et. al. 2022. “Enhanced Spatial Mapping of Histone Proteoforms in Human Kidney Through MALDI-MSI by High-Field UHMR Orbitrap Detection.” Analytical Chemistry. 94 (37): 12604. https://doi.org/10.1021/acs.analchem.2c01034

2021

Zemaitis K.J. et al. 2021. “Direct Infusion Metabolomics of a Drought Tolerant Plant Introduction Soybean Cultivar.” Metabolites. 11: 843. https://doi.org/10.3390/metabo11120843

Zemaitis K.J et al. 2021. “Streamlined DESI and MALDI Multimodal Mass Spectrometry Imaging on a Single Dual-Source Mass Spectrometer.” Metabolites 11: 253. https://doi.org/10.3390/metabo11040253

Zemaitis K.J. et al. 2021. “Mass Spectrometry Imaging of Blast-overpressure Induced modulation of GABA/Glutamate Homeostasis in the Central Auditory Neuraxis of Chinchilla.” Experimental and Molecular Pathology 119: 104605. https://doi.org/10.1016/j.yexmp.2021.104605

2020

Sekera E.R. et al. 2020. “MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord.” Journal of the American Society for Mass Spectrometry. 31 (12): 2462-2468. https://doi.org/10.1021/jasms.0c00187

Zemaitis and Wood. 2020. “Integration of 3D-printing for a desorption electrospray ionization source for mass spectrometry.” Review of Scientific Instruments 91 (10): 104102. https://doi.org/10.1063/5.0004626