Adam Osinski

University of Texas Southwestern Medical Center

Projects

Structural basis for SidJ-catalyzed polyglutamylation of the SidE all-in-one ubiquitin ligases

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Vincent Tagliabracci

Enzymes with a protein kinase fold transfer phosphate from ATP to substrates in a process known as phosphorylation. We have discovered that the Legionella meta-effector SidJ adopts a protein kinase…