Adam Swensen

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Type 1 diabetes (T1D) is a complex autoimmune disease. Recent clinical studies show that pancreatic beta-cell dysfunction (e.g., a decline of first phase insulin release) occurs several years before…

Multiplex Mass Spectrometric Protein Assays for Obesity

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

The prevalence of overweight and obesity has increased dramatically in recent decades in both children and adults, reaching an epidemic proportion. In order to gain new insights into the…

A Metabolomic Approach For Characterizing Methylenetetrahydrofolate Reductase Mutations And Possible Outcomes For The Treatment of Related Diseases

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Kathleen McAteer

Project type

Large-Scale EMSL Research

N5,N10-Methylenetetrahydrofolate reductase (MTHFR) is a flavoprotein that catalyzes the conversion of N5,N10-methylenetetrahydrofolate to N5-methyltetrahydrofolate. This reaction is required for the…

NMR Analysis of Bioprocess Samples

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Kathleen McAteer

Project type

Large-Scale EMSL Research

The overall project is directed towards utilization of filamentous fungi for conversion of complex biomass to industrial commodity chemicals biofuels, organic acids or chemical feed-stocks for other…

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

In type 1 diabetes (T1D) research there remains a critical need for having a systems level understanding of the early stage molecular mechanisms that trigger the specific destruction of pancreatic β…

Serum biomarkers for predicting type 1 diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Clinical type 1 diabetes (T1D) is preceded by an asymptomatic phase of the disease, which can be readily identified by serum islet autoantibodies(AAb). However, the T1D field is challenged by the…

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Type 1 diabetes (T1D) is a complex autoimmune disease. Recent clinical studies show that pancreatic beta-cell dysfunction (e.g., a decline of first phase insulin release) occurs several years before…

EMSL Science Overview

Adam Swensen

Projects

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes

Multiplex Mass Spectrometric Protein Assays for Obesity

A Metabolomic Approach For Characterizing Methylenetetrahydrofolate Reductase Mutations And Possible Outcomes For The Treatment of Related Diseases

NMR Analysis of Bioprocess Samples

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Serum biomarkers for predicting type 1 diabetes

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes