Ann Campbell

University of Washington

Projects

MUC1 Humoral Immune Recognition: Mapping Antibody-Tumor Associated Antigen Interactions

Lead Institution

University of Washington

Principal Investigator

Ann Campbell

Project type

Capability Research

Mucin 1 (MUC1), a glycopeptide tumor associated antigen, provides an excellent target for the design of a breast cancer vaccine due to its overexpression in 90% of breast cancers. The MUC1…

Drug Interactions of Human and Bacterial Cytochrome P450?s Probed by Pulsed Electron Paramagnetic Spectroscopy

Lead Institution

University of Washington

Principal Investigator

Ann Campbell

Project type

Capability Research

We are interested in using pulsed electron paramagnetic resonance (EPR) techniques that are available at the EMSL facility to probe drug interactions to and structure of cytochrome P450?s. We are…

Structure and Dynamics of MUC1 Immune Recognition: Significance for Breast Cancer Vaccine Design

Lead Institution

University of Washington

Principal Investigator

Ann Campbell

Project type

Capability Research

Generation of a cytotoxic T lymphocyte (CTL) immune response requires an antigenic peptide to be presented to the T cell receptor by Class I MHC molecules. Low affinity MHC Class I-associated…