Baohua Chen

University of California, Irvine

0000-0003-1702-188x

Projects

Structural studies of large clostridium toxins

Lead Institution

University of California, Irvine

Principal Investigator

Rongsheng Jin

Bacterial toxins are virulence factors that manipulate host cell functions and cause a myriad of serious diseases. We propose two aims to study the structure and function of Clostridium difficile…

Structural basis for recognition of receptor CSPG4 by Clostridium difficile toxin B

Lead Institution

University of California, Irvine

Principal Investigator

Rongsheng Jin

Clostridium difficile (C. diff) is an opportunistic pathogen, which establishes in the colon when the gut microbiota is disrupted by antibiotics or diseases. C. difficile infection (CDI) leads to…