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Darren Begley

Institution
Emerald BioStructures

Projects

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationship of human telomerase, the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini …

Assembly of the mRNA 3'-end processing machinery

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Large-Scale EMSL Research
We propose to use NMR to study the structural basis for the assembly of the protein complex responsible for the formation of mature 3'-ends of mRNAs by cleavage and polyadenylation, and the…

Structural Genomics Center for Infectious Diseases - Year III

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
New medicines are urgently needed against infectious diseases that are becoming increasingly more resistant to current therapies. The strategy being used by the National Institute of Health (NIH) to…