Gian Paola Grant

California State University, Los Angeles

Projects

Measuring nanometer distances in the packaging RNA using Double Electron-Electron Resonance.

Lead Institution

University of Southern California

Principal Investigator

Peter Qin

Project type

Capability Research

We request instrument time on the EMSL pulse electron paramagnetic resonance (EPR) system in order to measure nanometer distances in nucleic acids using the Double Electron-Electron Resonance (DEER)…

Measuring nanometer distances in the packaging RNA using Double Electron-Electron Resonance.

Lead Institution

University of Southern California

Principal Investigator

Peter Qin

Project type

Exploratory Research

In this renewal application we request to continue to use the pulsed EPR spectrometer at EMSL. We will use the instrument to measure nanometer distances in a complex of the packaging RNA (pRNA),…

Using electron paramagnetic resonance to study iron binding sites with alpha-synuclein, a protein marker for Parkinson's disease

Lead Institution

California State University, Los Angeles

Principal Investigator

Feimeng Zhou

Project type

Exploratory Research

In Parkinson's disease, the brains of affected patients were found to contain aggregated alpha-synuclein (a-syn) protein and high levels of iron (Fe2+ and Fe3+). Iron was found to binding a-syn,…