Jeffrey Grinstead

University of Washington

Projects

Structure and Dynamics of MUC1 Immune Recognition: Significance for Breast Cancer Vaccine Design

Lead Institution

University of Washington

Principal Investigator

Ann Campbell

Project type

Capability Research

Generation of a cytotoxic T lymphocyte (CTL) immune response requires an antigenic peptide to be presented to the T cell receptor by Class I MHC molecules. Low affinity MHC Class I-associated…

MUC1 Humoral Immune Recognition: Mapping Antibody-Tumor Associated Antigen Interactions

Lead Institution

University of Washington

Principal Investigator

Ann Campbell

Project type

Capability Research

Mucin 1 (MUC1), a glycopeptide tumor associated antigen, provides an excellent target for the design of a breast cancer vaccine due to its overexpression in 90% of breast cancers. The MUC1…