Kaylyn Cassens

FRET-Based Molecular Dynamics Simulation of Membrane-Receptor Activation

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Large-Scale EMSL Research

This proposal is a continuation of research pursued under EMSL User Proposals #6494 and #6493. Membrane receptors are activated upon the binding of small ligand molecules to specific sites in their…

Pathways and fate of individual nanoparticles in vivo; a whole organism approach

Lead Institution

Oregon State University

Principal Investigator

Robert Tanguay

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of amorphous silica nanoparticles. Adverse…

Nanoparticle-Cell Interactions and Intracellular Fate; Roles of Particle Surface Properties

Lead Institution

Oregon State University

Principal Investigator

Bettye Maddux

Project type

Large-Scale EMSL Research

The growing commerce in micro- and nanotechnology is expected to increase human exposure to submicrometer and nanoscale particles, including certain forms of gold and amorphous silica. Adverse…

Physicochemical determinants of distribution and fate of nanoparticles following in vivo exposure

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Justin Teeguarden

Project type

Large-Scale EMSL Research

The risks associated with the use of nanomaterials have been recently under investigation (1) as increasingly more nanosized products are developed and commercialized. The advent of nanotoxicology as…

Dynamic Changes in Molecular Interactions along the Circadian Rhythm (Orr-LDRD Membrane Biology GC, PNNL Scope #90001)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Grand Challenge

One of the most challenging tasks in cell biology is the study of the molecular interactions in the natural cellular environment in order to gain information about their dynamic changes in time and…

Roles for Membrane Receptors in Cellular Responses to External Cues; The Case of ErbB4 and Morphology Dynamics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Large-Scale EMSL Research

This proposal is a continuation of research pursued under EMSL User Proposal #22092. Understanding the mechanisms that underlie the cellular responses to the environment has been the subject of…

Nanoscale Characterization of Nanomaterial - Cell Interactions

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Galya Orr

Project type

Large-Scale EMSL Research

This proposal is a continuation of research pursued under EMSL User Proposal #17690. The extensive use of amorphous silica nanoparticles (NPs) in the industry, and the growing use of carbon nanotubes…

EMSL Science Overview

Kaylyn Cassens

Projects

FRET-Based Molecular Dynamics Simulation of Membrane-Receptor Activation

Pathways and fate of individual nanoparticles in vivo; a whole organism approach

Nanoparticle-Cell Interactions and Intracellular Fate; Roles of Particle Surface Properties

Physicochemical determinants of distribution and fate of nanoparticles following in vivo exposure

Dynamic Changes in Molecular Interactions along the Circadian Rhythm (Orr-LDRD Membrane Biology GC, PNNL Scope #90001)

Roles for Membrane Receptors in Cellular Responses to External Cues; The Case of ErbB4 and Morphology Dynamics

Nanoscale Characterization of Nanomaterial - Cell Interactions