Skip to main content

Leonard Spicer

Institution
Duke University

Projects

Measurement of Long Range NOE's in Perdeuterated Proteins

Lead Institution
Duke University
Principal Investigator
Leonard Spicer
Project type
Capability Research
We propose to continue with the project as described earlier in our previous request for instrument time. In addition we are interested in using the 800 MHz spectrometer to evaluate the impact of…

Structural Studies of HIV-1 gp41 MPER and HR-2 Membrane Associated Trimers

Lead Institution
Duke University
Principal Investigator
Leonard Spicer
Project type
Large-Scale EMSL Research
HIV-1 viral-host cell fusion is mediated by the envelope associated gp41 and gp120 protein trimers. The membrane proximal external region (MPER) of gp41 contains the epitopes for the broadly…