Mischelle Schutz

Integrated multi-modal approach for structure and function determination of lignin-forming protein complexes isolated from plants

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

We propose to apply an integrated multi-modal structural biology approach to investigate a biosynthetic protein complex in plants that is hypothesized to organize and guide lignin biosynthesis via…

Impact of apolipoprotein E isoforms on brain lipoproteins

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Melchior

Cerebrovascular dysfunction leads to the deposition of amyloid plaques and neurofibrillary tangles in the brain which underlie the development of Alzheimer’s disease (AD); an epidemic that…

The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Melchior

Apolipoprotein (apo)A-II is an abundant human plasma protein primarily in high-density lipoproteins (HDL) but also in very low density lipoproteins (VLDL) and chylomicrons. Despite a large literature…

Detergent-free extraction of membrane proteins and lipids from native cells

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Melchior

Membrane proteins account for >30% of most genomes, yet only make up <4% of reported high-resolution structures in the protein data bank. Current approaches for isolating membrane proteins from…

EMSL Science Overview

Mischelle Schutz

Projects

Integrated multi-modal approach for structure and function determination of lignin-forming protein complexes isolated from plants

Impact of apolipoprotein E isoforms on brain lipoproteins

The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism

Detergent-free extraction of membrane proteins and lipids from native cells