Ronald de Vries

Expanding synthetic biology tools by deeper understanding of Aspergillus niger primary metabolism

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

FICUS Research

Fungal primary carbon metabolism consists of many connected pathways to convert monosaccharides and other monomeric carbon sources. While many of the pathways have been described as single enzyme per…

Dissecting intraspecies diversity in fungal wood decay

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

FICUS Research

Basidiomycete fungi are essential for degradation of wood in natural eco-systems and therefore a crucial part of the global carbon cycle. Genomic and post-genomic studies into several basidiomycete…

Visualizing plant biomass degradation by Aspergillus niger

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Special Science

Aspergillus niger is an ascomycete fungus with a long history of industrial use for the production of organic acids and enzymes. Its ability to degrade plant biomass has been well studied and it…

Genomes to dynamic decay communities: Understanding fungal interactions during early decomposition events in natural lignocellulosic substrate

Lead Institution

Swansea University

Principal Investigator

Dan Eastwood

Project type

FICUS Research

Understanding the microbial decomposition of lignocellulose and its contribution to global carbon cycling requires realistic model systems that go beyond in silico and single culture analyses. Fungal…

Colony plasticity of filamentous fungi

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Exploratory Research

We will use the ascomycete industrial workhorse A. niger, which is one of the best studied fungal species with respect to plant biomass conversion. In nature, fungal colonies can cover substantial…

Colony plasticity of filamentous fungi

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Limited Scope

Thee ascomycete industrial workhorse A. niger is one of the best studied fungal species with respect to plant biomass conversion. In nature, fungal colonies can cover substantial areas in which the…

Validation of metabolic models, extrapolated from the reference sugar catabolism genetic network of Aspergillus niger by using an orthology-based approach, of evolutionarily diverse fungi

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

FICUS Research

Sugar conversion through central carbon catabolism in filamentous fungi is a complex process that involves many pathways, some with shared and/or redundant components. During growth on plant biomass,…

Experimental validation of a central carbon metabolic model in Aspergillus niger to enable metabolic engineering of this fungal cell factory

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Exploratory Research

Sugar conversion through central carbon catabolism in filamentous fungi is a complex progress that involves many pathways. During growth on plant biomass, multiple 5- and 6-carbon monomeric sugars…

Dissecting the central metabolic network of Aspergillus niger during growth on plant biomass

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Exploratory Research

Sugar conversion through central carbon catabolism in filamentous fungi is a complex progress that involves many pathways. Using the high quality manually curated genome sequence of Aspergillus niger…

EMSL Science Overview

Ronald de Vries

Projects

Expanding synthetic biology tools by deeper understanding of Aspergillus niger primary metabolism

Dissecting intraspecies diversity in fungal wood decay

Visualizing plant biomass degradation by Aspergillus niger

Genomes to dynamic decay communities: Understanding fungal interactions during early decomposition events in natural lignocellulosic substrate

Colony plasticity of filamentous fungi

Colony plasticity of filamentous fungi

Validation of metabolic models, extrapolated from the reference sugar catabolism genetic network of Aspergillus niger by using an orthology-based approach, of evolutionarily diverse fungi

Experimental validation of a central carbon metabolic model in Aspergillus niger to enable metabolic engineering of this fungal cell factory

Dissecting the central metabolic network of Aspergillus niger during growth on plant biomass