Ting Liu

Montana State University

Projects

Determination of the CCR5 and CXCR4 Antagonist and Agonist Binding Site.

Lead Institution

Montana State University

Principal Investigator

Edward Dratz

Project type

Limited Scope

This proposal focuses on determining the locations of the agonist and antagonist binding pockets for the 7-transmembrane spanning G-Protein coupled receptors (GPCR) CCR5 and CXCR4. G-protein coupled…

Analysis of Photo-crosslinking Sites of Antagonists and Agonists in CCR5 and CXCR4

Lead Institution

Montana State University

Principal Investigator

Edward Dratz

Project type

Large-Scale EMSL Research

The primary objective of our proposed studies are to characterize the residues on CCR5 and CXCR4 (likely to be deep within biological membranes) that directly mediate the interactions with agonist…