Triona Matheson

Oregon Health & Science University

0000-0002-7764-909x

Projects

Development of Copper Storage Protein Csp1 as an Electron-Dense “Bio Tag” for Facilitating Structural Determination of Small (< 100 kDa) Proteins by single-particle Cryo EM Methods.

Lead Institution

Oregon Health & Science University

Principal Investigator

David Farrens

Small (< 100 kDa) proteins are challenging to study by standard single-particle cryo-EM techniques, due to their very low signal to noise ratios in images. Heavy atoms could potentially overcome…

Novel biochemical methods for facilitating GPCR tertiary and quaternary structure determination by cryo-EM.

Lead Institution

Oregon Health & Science University

Principal Investigator

David Farrens

GPCRs are the largest family of membrane proteins in the human genome, and a major target of pharmaceutical drugs. However, relatively few GPCR structures are known. Moreover, many GPCRs are known…