Xuepeng Wei

University of Pennsylvania

0000-0002-6514-7076

Projects

Cryo-EM structure of the human ATP-citrate lyase (ACLY) bound to inhibitors

Lead Institution

University of Pennsylvania

Principal Investigator

Ronen Marmorstein

The goal of this project is to determine the cryo-EM structure of the human ATP-citrate lyase (ACLY) multimer bound to inhibitors to better understand the mechanism of ACLY activity and to generate a…

Molecular mechanisms and inhibition of metabolic acyltransferase enzymes

Lead Institution

University of Pennsylvania

Principal Investigator

Ronen Marmorstein

The goal of this project is to determine the cryo-EM structures of metabolic acyltransferase enzymes in functionally relevant reaction states and bound to inhibitors to elucidate their molecular…