Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Rugged Nanoparticle Tracers

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lance Hubbard

Tracing the flow of solid matter requires elements with uniquely identifiable signatures. Pigments tagged with luminescent core-shell nanoparticles (CSNPs) can have tunable photoluminescence (PL)…

Structural basis for biological force sensations

Lead Institution

University of California, Berkeley

Principal Investigator

Stephen Brohawn

The goal of this proposal is to understand how cells sense and respond to physical stimuli. The ability to detect physical forces underlies classic mechanosensations like hearing and less conspicuous…

Multimodal Chemical Imaging Across Scales to Visualize Metabolic Pathways in Live Plants and Microbial Systems

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Lea

We will develop a novel spectral imaging platform (“BioImager”) that may be used to image and identify biomolecules involved in both microbial and plant metabolic processes through different chemical…

Metabolomic and Lipidomic Analysis of Subjects with Galactosemia

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jennifer Kyle

Galactosemia is a rare, genetic, metabolic disease affecting how the body processes galactose. Classical galactosemia, affecting 1 in 30,000 to 60,000 newborns, is a severe form of the disease…

radAFM: Coupled radiation source/liquid-cell AFM to study radiation-induced interfacial processes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gregory Kimmel

Millions of liters of high-level radioactive wastes (HLW) stored in hundreds of tanks in the U.S. create a variety of environmental problems. To mitigate these problems, the wastes are intended to be…

Non-thermal Reactions at Surfaces and Interfaces, and in Model Aqueous Systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gregory Kimmel

Energetic processes at surfaces and interfaces are important in fields such as radiation chemistry, radiation biology, waste processing, and advanced materials synthesis. Low-energy electrons (&lt…

Computational modeling to design electrocatalysts for energy storage production

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Simone Raugei

We propose to use EMSL supercomputing resources to computationally design and predict new catalysts for energy storage reactions, as well as model the interface between electrodes and catalyst. This…

Cryo-EM Structural Studies of Lentiviral Intasomes

Lead Institution

Salk Institute for Biological Studies

Principal Investigator

Dmitry Lyumkis

A distinct feature of all retroviruses is the ability to integrate their viral DNA (vDNA) into cellular DNA to ensure permanent infection. This process in vivo is catalyzed by the preintegration…

Structural characterization of immunogens in complex with antibodies for structure-based vaccine design

Lead Institution

Fred Hutchinson Cancer Research Center

Principal Investigator

Marie Pancera

Although to-date numerous vaccines exist, their mechanism of protection is not always understood. Additionally, there are pathogens such as HIV and Malaria for which vaccines do not exist. Our…

Use of In-situ SS NMR to investigate hydrogen dissolved in rubber materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yongsoon Shin

The main aim of this proposal is to identify hydrogen species (free, dissolved, or reacted) in two types of rubber materials, acrylonitrile butadiene rubber (NBR) and ethylene propylene diene monomer…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Crystal face influence on hematite-organic ligand interactions at iron oxide/water interfaces studied using nonlinear spectroscopy techniques

Lead Institution

University of Puget Sound

Principal Investigator

Amanda Mifflin

The proposed work will examine the interfacial phenomena of the organic ligand acetohydroxamic acid (aHa) at the hematite/water interface and the molecular structure at organic/aqueous interface…

Irradiation induced changes in TPBAR Components by Atom Probe Tomography

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Arun Devaraj

Tritium-producing burnable absorber rods (TPBARs) used in the U.S. Department of Energy’s Tritium Readiness Program are designed to produce tritium when irradiated in a nuclear reactor. The exterior…

Towards an atomic-resolution structure of the universal microtubule nucleator: the gamma-tubulin ring complex

Lead Institution

New York University School of Medicine

Principal Investigator

Gira Bhabha

Formation of microtubules (MT) is the basis for segregation of chromosomes during mitosis and establishing the cellular cytoskeleton. MT formation relies on multiple MT nucleation pathways that need…

Development of a single-cell top-down proteomics platform for understanding rhizobial infection process

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ying Zhu

We aim to extend EMSL’s leading capability in ultrasensitive/single cell proteomics to measure intact proteins in individual plant cells. We will address major challenges in ultrasensitive top down…

Structural characterization of TRPA1 ion channel in complex with selective agonists

Lead Institution

Genentech, Inc.

Principal Investigator

Alexis Rohou

Our aim is to determine the structures of agonists bound to TRPA1, a ligand-gated ion channel and polymodal receptor implicated in pain, itch and respiratory diseases. Electrophilic agonists, such…

Structural insights into the regulation of MDA5-mediated antiviral signaling activity

Lead Institution

Boston Children's Hospital

Principal Investigator

Sun Hur

Effective antiviral immunity involves the recognition of viral dsRNA by the innate immune receptor MDA5 and the subsequent interferon signaling cascade. Aberrant recognition of endogenous “self” RNAs…

Protein complexes involved in building and maintaining the bacterial cell envelope

Lead Institution

New York University School of Medicine

Principal Investigator

Gira Bhabha

In double-membraned bacteria, the outer membrane forms a barrier between the cell and the outside world, and acts as the first line of defense against the environment. The outer membrane in double…

Noble Gas Transport in Variably Saturated Porous Media

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mark Rockhold

Building and refining the capability to detect and locate suspected subsurface nuclear explosions are part of United States’ security priorities (Broome et al., 2016). To improve understanding of…

Identifying aqueous SOA tracers from oxidation of phenols in biomass burning aerosols

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

ManishKumar Shrivastava

Recent DOE- supported field measurements provide a wealth of high resolution mass spectrometry data using instruments such as HR-ToF-AMS and SPLAT II over different locations (e.g. over Oklahoma City…

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