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Nikola Tolic
Data Scientist

Nikola Tolic is a data scientist with the Research Software Engineering and Data Science team. Since joining EMSL in 2001, he has been involved in mass spectrometry data handling, processing, and delivery. He was also involved in the transfer of PNNL-designed technology for data management to Washington State University in a collaborative project on protein-protein interactions.

Tolic serves as a proteomics research resource for integrative biology and is focused on serving the National Institutes of Health-supported biomedical research community by developing and integrating new proteomic technologies for collaborative and service studies, disseminating the new technologies, and training scientists in their use. He also develops calculation methods for precise measurements of proteome proteins and their post-translational modifications.

Through his involvement in various PNNL internship programs, he has mentored several high school students and interns.

Education

BS in Mathematics, University of Zagreb, 1990

Publications

2020

Hawkes J., J. D'Andrilli, J.N. Agar, M. Barrow, S. Berg, N. Catalan, and H. Chen, et al. 2020. "An international laboratory comparison of dissolved organic matter composition by high resolution mass spectrometry: Are we getting the same answer?." Limnology and Oceanography Methods 18, no. 6:235-258. PNNL-SA-147033. doi:10.1002/lom3.10364

Morrison, E. S., M. R. Shields, T. S. Bianchi, Y. Liu, S. Newman, N. Tolić, and R. K. Chu. 2020. “Multiple Biomarkers Highlight the Importance of Water Column Processes in Treatment Wetland Organic Matter Cycling.” Water Research 168. https://doi.org/10.1016/j.watres.2019.115153.

Noël, V., N. Kumar, K. Boye, L. Barragan, J. S. Lezama-Pacheco, R. Chu, N. Tolić, G. E. Brown, and J. R. Bargar. 2020. “Fes Colloids-Formation and Mobilization Pathways in Natural Waters.” Environmental Science: Nano 7 (7): 2102-2116. https://doi.org/10.1039/c9en01427f.

Samarah L.Z., R. Khattar, T.H. Tran, S.A. Stopka, C.A. Brantner, P. Parlanti, and D. Velickovic, et al. 2020. "Single-Cell Metabolic Profiling: Metabolite Formulas from Isotopic Fine Structures in Heterogeneous Plant Cell Populations." Analytical Chemistry 92, no. 10:7289-7298. PNNL-SA-152789. doi:10.1021/acs.analchem.0c00936

2019

Yang, J., H. Jiang, W. Liu, L. Huang, J. Huang, B. Wang, H. Dong, R. K. Chu, and N. Tolić. 2020. “Potential Utilization of Terrestrially Derived Dissolved Organic Matter by Aquatic Microbial Communities in Saline Lakes.” ISME Journal 14 (9): 2313-2324. https://doi.org/10.1038/s41396-020-0689-0.

Fudyma J.D., J.E. Lyon, R. Aminitabrizi, H. Gieschen, R.K. Chu, D.W. Hoyt, and J.E. Kyle, et al. 2019. "Untargeted metabolomic profiling of Sphagnum fallax reveals novel antimicrobial metabolites." Plant Direct 3, no. 11:Article No. e00179. PNNL-SA-146621. doi:10.1002/pld3.179

Nuñez, J. R., S. M. Colby, D. G. Thomas, M. M. Tfaily, N. Tolić, E. M. Ulrich, J. R. Sobus, T. O. Metz, J. G. Teeguarden, and R. S. Renslow. 2019. “Evaluation of in Silico Multifeature Libraries for Providing Evidence for the Presence of Small Molecules in Synthetic Blinded Samples.” Journal of Chemical Information and Modeling 59 (9): 4052-4060. https://doi.org/10.1021/acs.jcim.9b00444.

Zhou, Z., T. Yu, H. Dong, L. Huang, R. K. Chu, N. Tolić, X. Wang, and Q. Zeng. 2019. “Chemical Oxygen Demand (COD) Removal from Bio-Treated Coking Wastewater by Hydroxyl Radicals Produced from a Reduced Clay Mineral.” Applied Clay Science 180. https://doi.org/10.1016/j.clay.2019.105199.

Shen Y., R. Zhao, N. Tolic, M. Tfaily, E.W. Robinson, R.M. Boiteau, and L. Pasa Tolic, et al. 2019. "Online supercritical fluid extraction mass spectrometry (SFE-LC-FTMS) for sensitive characterization of soil organic matter." Faraday Discussions 218. PNNL-SA-141115. doi:10.1039/C9FD00011A

2018

Chen H., Z. Yang, R.K. Chu, N. Tolic, L. Liang, D.E. Graham, and S.D. Wullschleger, et al. 2018. "Molecular Insights into Arctic Soil Organic Matter Degradation under Warming." Environmental Science & Technology 52, no. 8:4555-4564. PNNL-SA-136151. doi:10.1021/acs.est.7b05469

Rivas-Ubach A., Y. Liu, T.S. Bianchi, N. Tolic, G.C. Jansson, and L. Pasa Tolic. 2018. "Moving beyond the van Krevelen diagram: A new stoichiometric approach for compound classification in organisms." Analytical Chemistry 90, no. 10:6152-6160. PNNL-SA-134250. doi:10.1021/acs.analchem.8b00529

2017

Blair S.L., A.C. Macmillan, G.T. Drozd, A.H. Goldstein, R.K. Chu, L. Pasa Tolic, and J.B. Shaw, et al. 2017. "Molecular Characterization of Organosulfur Compounds in Biodiesel and Diesel Fuel Secondary Organic Aerosol." Environmental Science & Technology 51, no. 1:119-127. PNNL-SA-119437. doi:10.1021/acs.est.6b03304

Cook R.D., Y. Lin, Z. Peng, E.J. Boone, R.K. Chu, J.E. Dukett, and M.J. Gunsch, et al. 2017. "Biogenic, urban, and wildfire influences on the molecular composition of dissolved organic compounds in cloud water." Atmospheric Chemistry and Physics 17, no. 24:15167-15180. PNNL-SA-130575. doi:10.5194/acp-17-15167-2017

Kou Q., S. Wu, N. Tolic, L. Pasa Tolic, Y. Liu, and X. Liu. 2017. "A mass graph-based approach for the identification of modified proteoforms using top-down tandem mass spectra." Bioinformatics 33, no. 9:1309-1316. PNNL-SA-123090. doi:10.1093/bioinformatics/btw806

Park J., P.D. Piehowski, C.S. Wilkins, M. Zhou, J.A. Mendoza, G.M. Fujimoto, and B.C. Gibbons, et al. 2017. "Informed-Proteomics: Open Source Software Package for Top-down Proteomics." Nature Methods 14, no. 9:909-914. PNNL-SA-120171. doi:10.1038/nmeth.4388

Shen Y., N. Tolic, P.D. Piehowski, A.K. Shukla, S. Kim, R. Zhao, and Y. Qu, et al. 2017. "High-resolution ultrahigh-pressure long column reversed-phase liquid chromatography for top-down proteomics." Journal of Chromatography A 1498. PNNL-SA-104738. doi:10.1016/j.chroma.2017.01.008

Tfaily M.M., R.K. Chu, J.G. Toyoda, N. Tolic, E.W. Robinson, L. Pasa Tolic, and N.J. Hess. 2017. "Sequential extraction protocol for organic matter from soils and sediments using high resolution mass spectrometry." Analytica Chimica Acta 972. PNNL-SA-125053. doi:10.1016/j.aca.2017.03.031

Tolic N., Y. Liu, A.V. Liyu, Y. Shen, M.M. Tfaily, E.B. Kujawinski, and K. Longnecker, et al. 2017. "Formularity: Software for Automated Formula Assignment of Natural and Other Organic Matter from Ultra-High Resolution Mass Spectra." Analytical Chemistry 89, no. 23:12659-12665. PNNL-SA-128094. doi:10.1021/acs.analchem.7b03318

2016

Anderton C.R., R.K. Chu, N. Tolic, A.V. Creissen, and L. Pasa-Tolic. 2016. "Utilizing a Robotic Sprayer for High Lateral and Mass Resolution MALDI FT-ICR MSI of Microbial Cultures." Journal of the American Society for Mass Spectrometry 27, no. 3:556-559. PNNL-SA-115142. doi:10.1007/s13361-015-1324-6

Kaplan D.I., C. Xu, S. Huang, Y. Lin, N. Tolic, K.M. Roscioli, and P.H. Santschi, et al. 2016. "Unique Organic Matter and Microbial Properties in the Rhizosphere of a Wetland Soil." Environmental Science & Technology 50, no. 8:4169-4177. PNNL-SA-117429. doi:10.1021/acs.est.5b05165

Kou Q., B. Zhu, S. Wu, C.K. Ansong, N. Tolic, L. Pasa Tolic, and X. Liu. 2016. "Characterization of Proteoforms with Unknown Post-translational Modifications Using the MIScore." Journal of Proteome Research 15, no. 8:2422-2432. PNNL-SA-119698. doi:10.1021/acs.jproteome.5b01098

Shaw J.B., T. Lin, F.E. Leach, A.V. Tolmachev, N. Tolic, E.W. Robinson, and D.W. Koppenaal, et al. 2016. "21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer Greatly Expands Mass Spectrometry Toolbox." Journal of the American Society for Mass Spectrometry 27, no. 12:1929-1936. PNNL-SA-121061. doi:10.1007/s13361-016-1507-9

Sun J., T. Dutta, R. Parthasarathi, K. Kim, N. Tolic, R.K. Chu, and N.G. Isern, et al. 2016. "Rapid room temperature solubilization and depolymerization of polymeric lignin at high loadings." Green Chemistry 18, no. 22:6012-6020. PNNL-SA-120307. doi:10.1039/C6GC02258H

Tolic N., M.M. Tfaily, Y. Shen, R.K. Chu, T.L. Fillmore, R. Zhao, and K.J. Bloodsworth, et al. 2016. "Soil Organic Matter (SOM): Mass Spectrometry Data Analysis." In Encyclopedia of Soil Science, Third Edition, edited by R Lal. Boca Raton, Florida:CRC Press. PNNL-SA-117244. doi:10.1081/E-ESS3-120053757

Vyatkina K., S. Wu, L.J. Dekker, M.M. vanDuijn, X. Liu, N. Tolic, and T.M. Luider, et al. 2016. "Top-down analysis of protein samples by de novo sequencing techniques." Bioinformatics 32, no. 18:2753-2759. PNNL-SA-119182. doi:10.1093/bioinformatics/btw307

2015

Mann B.F., H. Chen, E.M. Herndon, R.K. Chu, N. Tolic, E. Portier, and T.R. Chowdhury, et al. 2015. "Indexing Permafrost Soil Organic Matter Degradation Using High-Resolution Mass Spectrometry." PLoS One 10, no. 6:Article No. e0130557. PNNL-SA-111173. doi:10.1371/journal.pone.0130557

Tfaily M.M., R.K. Chu, N. Tolic, K.M. Roscioli, C.R. Anderton, L. Pasa-Tolic, and E.W. Robinson, et al. 2015. "Advanced solvent based methods for molecular characterization of soil organic matter by high-resolution mass spectrometry." Analytical Chemistry 87, no. 10:5206-5215. PNNL-SA-107718. doi:10.1021/acs.analchem.5b00116

Vyatkina K., S. Wu, L.J. Dekker, M.M. vanDuijn, X. Liu, N. Tolic, and M. Dvorkin, et al. 2015. "De novo sequencing of peptides from top-down tandem mass spectra." Journal of Proteome Research 14, no. 11:4450-4462. PNNL-SA-103863. doi:10.1021/pr501244v

Xu Z., C. Wu, F. Xie, G.W. Slysz, N. Tolic, M.E. Monroe, and V.A. Petyuk, et al. 2015. "Comprehensive Quantitative Analysis of Ovarian and Breast Cancer Tumor Peptidomes." Journal of Proteome Research 14, no. 1:422-433. PNNL-SA-103951. doi:10.1021/pr500840w

2014

Cao L., N. Tolic, Y. Qu, D. Meng, R. Zhao, Q. Zhang, and R.J. Moore, et al. 2014. "Characterization of intact N- and O-linked glycopeptides using higher energy collisional dissociation." Analytical Biochemistry 452. PNNL-SA-99189. doi:10.1016/j.ab.2014.01.003

Dang X., J. Scotcher, S. Wu, R.K. Chu, N. Tolic, I. Ntai, and P. Thomas, et al. 2014. "The first pilot project of the consortium for top-down proteomics: A status report." Proteomics 14, no. 10:1130-1140. PNNL-SA-102713. doi:10.1002/pmic.201300438

Dekker L.J., S. Wu, M.M. vanDuijn, N. Tolic, C. Stingl, R. Zhao, and T.n. Luider, et al. 2014. "An integrated top-down and bottom-up proteomic approach to characterize the antigen binding fragment of antibodies." Proteomics 14, no. 10:1239-1248. PNNL-SA-101637. doi:10.1002/pmic.201300366

Wu S., J.N. Brown, N. Tolic, D. Meng, X. Liu, H. Zhang, and R. Zhao, et al. 2014. "Quantitative Analysis of Human Salivary Gland-Derived Intact Proteome Using Top-Down Mass Spectrometry." Proteomics 14, no. 10:1211-1222. PNNL-SA-83095. doi:10.1002/pmic.201300378

2013

Halim M.F., F. Pfeiffer, J. Zou, A. Frisch, D.H. Haft, S. Wu, and N. Tolic, et al. 2013. "Haloferax volcanii archaeosortase is required for motility, mating, and C-terminal processing of the S-layer glycoprotein." Molecular Microbiology 88, no. 6:1164-1175. PNNL-SA-93808. doi:10.1111/mmi.12248

Liu X., S.M. Hengel, S. Wu, N. Tolic, L. Pasa-Tolic, and P.A. Pevzner. 2013. "Identification of Ultramodified Proteins Using Top-Down Mass Spectra." Journal of Proteome Research 12, no. 12:5830-8. PNNL-SA-94025. doi:10.1021/pr400849y

Liu X., S.M. Hengel, S. Wu, N. Tolic, L. Pasa-Tolic, and P.A. Pevzner. 2013. "Identification of ultramodified proteins using top-down spectra." In Research in Computational Molecular Biology: 17th Annual International Conference, April 7-10, 2013, Beijing, China. Lecture Notes in Computer Science, edited by M Deng, et al, 7821, 132-144. Berlin:Springer. PNNL-SA-93057. doi:10.1007/978-3-642-37195-0_11

Wu S., R.N. Brown, S.H. Payne, D. Meng, R. Zhao, N. Tolic, and L. Cao, et al. 2013. "Top-down characterization of the post-translationally modified intact periplasmic proteome of the bacterium Novosphingobium aromaticivorans." International Journal of Proteomics 2013. PNNL-SA-91327. doi:10.1155/2013/279590

2012

Shen Y., N. Tolic, S.O. Purvine, and R.D. Smith. 2012. "Improving Collision Induced Dissociation (CID), High Energy Collision Dissociation (HCD), and Electron Transfer Dissociation (ETD) Fourier Transform MS/MS Degradome-Peptidome Identifications Using High Accuracy Mass Information." Journal of Proteome Research 11, no. 2:668-677. PNNL-SA-79420.

Tian Z., N. Tolic, R. Zhao, R.J. Moore, S.M. Hengel, E.W. Robinson, and D.L. Stenoien, et al. 2012. "Enhanced top-down characterization of histone post-translational modifications." Genome Biology 13, no. 10:R86. PNNL-SA-90867. doi:10.1186/gb-2012-13-10-r86

2011

Ansong C., N. Tolic, S.O. Purvine, S. Porwollik, M.B. Jones, H. Yoon, and S.H. Payne, et al. 2011. "Experimental annotation of post-translational features and translated coding regions in the pathogen Salmonella Typhimurium." BMC Genomics 12. PNNL-SA-77195. doi:10.1186/1471-2164-12-433

Lopez-Ferrer D., K. Petritis, E.W. Robinson, K.K. Hixson, Z. Tian, J. Lee, and S. Lee, et al. 2011. "Pressurized Pepsin Digestion in Proteomics: An Automatable Alternative to Trypsin for Integrated Top-down Bottom-up Proteomics." Molecular & Cellular Proteomics. MCP 10, no. 2. PNNL-SA-71649. doi:10.1074/mcp.M110.001479

Shen Y., N. Tolic, F. Xie, R. Zhao, S.O. Purvine, A.A. Schepmoes, and R.J. Moore, et al. 2011. "Effectiveness of CID, HCD, and ETD with FT MS/MS for degradomic-peptidomic analysis: comparison of peptide identification methods." Journal of Proteome Research 10, no. 9:3929-3943. PNNL-SA-75441. doi:10.1021/pr200052c

Shen Y., N. Tolic, S.O. Purvine, and R.D. Smith. 2011. "Improving CID, HCD, and ETD FT MS/MS degradome-peptidome identifications using high accuracy mass information." Journal of Proteome Research. PNNL-SA-81060. doi:10.1021/pr200597j

Wu S., N. Tolic, Z. Tian, E.W. Robinson, and L. Pasa-Tolic. 2011. "An integrated top-down and bottom-up strategy for characterization protein isoforms and modifications." In Bioinformatics for Comparative Proteomics: Methods in Molecular Biology, edited by CH Wu and C Chen. 291-304. New York, New York:Springer. PNNL-SA-68814.

2010

Jung H., S.O. Purvine, H. Kim, V.A. Petyuk, S. Hyung, M.E. Monroe, and D. Mun, et al. 2010. "Integrated Post-Experiment Monoisotopic Mass Refinement: An Integrated Approach to Accurately Assign Monoisotopic Precursor Masses to Tandem Mass Spectrometric Data." Analytical Chemistry 82, no. 20:8510-8518. PNNL-SA-74157. doi:10.1021/ac101388b

Shen Y., N. Tolic, S.O. Purvine, and R.D. Smith. 2010. "Identification of Disulfide Bonds in Protein Proteolytic Degradation Products Using de Novo-Protein Unique Sequence Tags Approach." Journal of Proteome Research 9, no. 8:4053-4060. PNNL-SA-73098.

Shen Y., N. Tolic, T. Liu, R. Zhao, B.O. Petritis, M.A. Gritsenko, and D.G. Camp, et al. 2010. "Blood Peptidome-Degradome Profile of Breast Cancer." PLoS One 5, no. 10:Article No.: e13133. PNNL-SA-70095. doi:10.1371/journal.pone.0013133

Shen Y., T. Liu, N. Tolic, B.O. Petritis, R. Zhao, R.J. Moore, and S.O. Purvine, et al. 2010. "A strategy for degradomic-peptidomic analysis of the human blood plasma." Journal of Proteome Research 9, no. 5:2339-2346. PNNL-SA-71375. doi:10.1021/pr901083m

Tian Z., R. Zhao, N. Tolic, R.J. Moore, D.L. Stenoien, E.W. Robinson, and R.D. Smith, et al. 2010. "Two-dimensional liquid chromatography system for online top-down mass spectrometry." Proteomics 10, no. 20:3610-3620. PNNL-SA-73468. doi:10.1002/pmic.201000367

2009

Chowdhury S.M., X. Du, N. Tolic, S. Wu, R.J. Moore, M.U. Mayer, and R.D. Smith, et al. 2009. "Identification of Cross-Linked Peptides after Click-Based Enrichment Using Sequential Collision-Induced Dissociation and Electron Transfer Dissociation Tandem Mass Spectrometry." Analytical Chemistry 81, no. 13:5524-5532. PNNL-SA-61747. doi:10.1021/ac900853k

Wu S., F. Yang, R. Zhao, N. Tolic, E.W. Robinson, D.G. Camp, and R.D. Smith, et al. 2009. "An integrated workflow for characterizing intact phosphoproteins from complex mixtures." Analytical Chemistry 81, no. 11:4210-4219. PNNL-SA-63139. doi:10.1021/ac802487q

Wu S., N.M. Lourette, N. Tolic, R. Zhao, R. Robinson, A.V. Tolmachev, and R.D. Smith, et al. 2009. "An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications." Journal of Proteome Research 8, no. 3:1347-1357. PNNL-SA-58633.

Yang F., S. Wu, D.L. Stenoien, R. Zhao, M.E. Monroe, M.A. Gritsenko, and S.O. Purvine, et al. 2009. "Combined Pulsed-Q dissociation and electron transfer dissociation for identification and quantitation of iTRAQ-labeled phosphopeptides." Analytical Chemistry 81, no. 10:4137-4143. PNNL-SA-63701. doi:10.1021/ac802605m

Zhang H., X. Tang, G.R. Munske, N. Tolic, G.A. Anderson, and J.E. Bruce. 2009. "Identification of Protein-Protein Interactions and Topologies in Living Cells with Chemical Cross-linking and Mass Spectrometry." Molecular & Cellular Proteomics. MCP 8, no. 3:409-420. PNNL-SA-60535.

2008

Shen Y., K.K. Hixson, N. Tolic, D.G. Camp, S.O. Purvine, R.J. Moore, and R.D. Smith. 2008. "Mass Spectrometry Analysis of Proteome-wide Proteolytic Post-translational Degradation of Proteins." Analytical Chemistry 80, no. 15:5819-5828. PNNL-SA-58041. doi:10.1021/ac800077w

Shen Y., N. Tolic, K.K. Hixson, S.O. Purvine, G.A. Anderson, and R.D. Smith. 2008. "De novo sequencing of unique sequence tags for discovery of post-translational modifications of proteins." Analytical Chemistry 80, no. 20:7742-7754. PNNL-SA-60782. doi:10.1021/ac801123p

Shen Y., N. Tolic, K.K. Hixson, S.O. Purvine, L. Pasa-Tolic, W. Qian, and J.N. Adkins, et al. 2008. "Proteome-wide identification of proteins and their modifications with decreased ambiguities and improved false discovery rates using unique sequence tags." Analytical Chemistry 80, no. 6:1871-82. PNNL-SA-56012. doi:10.1021/ac702328x

Zhang H., X. Tang, G.R. Munske, N. Tolic, G.A. Anderson, and J.E. Bruce. 2008. "Identification of protein-protein interaction and topologies in living cells by chemical cross-linking and mass spectrometry." Molecular & Cellular Proteomics. MCP 8, no. 3:409-420. PNNL-SA-54794. doi:10.1074/mcp.M800232-MCP200

Zhang H., X. Tang, G.R. Munske, N.L. Zakharova, L. Yang, C. Zheng, and M.A. Wolff, et al. 2008. "In Vivo Identification of the Outer Membrane Protein OmcA-MtrC Interaction Network in Shewanella oneidensis MR-1 Cells Using Novel Hydrophobic Chemical Cross-Linkers." Journal of Proteome Research 7, no. 4:1712-1720. PNNL-SA-59029. doi:10.1021/pr7007658

2007

Anderson G.A., N. Tolic, X. Tang, C. Zheng, and J.E. Bruce. 2007. "Informatics Strategies for Large-Scale Novel Cross-linking Analysis." Journal of Proteome Research 6, no. 9:3412-3421. PNNL-SA-54795. doi:10.1021/pr070035z

Anderson G.A., N. Tolic, X. Tang, C. Zheng, and J.E. Bruce. 2007. "Informatics Strategies for Large-Scale Novel Cross-linking Analysis." Journal of Proteome Research 6, no. 9:3412-3421. PNNL-SA-56252. doi:10.1021/pr070035z

Monroe M.E., N. Tolic, N. Jaitly, J.L. Shaw, J.N. Adkins, and R.D. Smith. 2007. "VIPER: an advanced software package to support high-throughput LC-MS peptide identification." Bioinformatics 23, no. 15- August 2007:2021-2023. PNNL-SA-52622. doi:10.1093/bioinformatics/btm281

Sharma S., D.C. Simpson, N. Tolic, N. Jaitly, A.M. Mayampurath, R.D. Smith, and L. Pasa-Tolic. 2007. "Proteomic profiling of intact proteins using WAX-RPLC 2-D separations and FTICR mass spectrometry." Journal of Proteome Research 6, no. 2:602-610. PNNL-SA-50906. doi:10.1021/pr060354a

2006

Elshafey A., N. Tolic, M.M. Young, K.L. Sale, R.D. Smith, and V. Kery. 2006. "Zero-length Cross-linking in Solid State as an Approach for Analysis of Protein -Protein Interactions." Protein Science 15, no. 3:429-440. PNNL-SA-46071.

Kiebel G.R., K.J. Auberry, N. Jaitly, D. Clark, M.E. Monroe, E.S. Peterson, and N. Tolic, et al. 2006. "PRISM: A Data Management System for High-Throughput Proteomics." Proteomics 6, no. 6:1783-1790. PNNL-SA-45753. doi:10.1002/pmic.200500500

Lipton M.S., M.F. Romine, M.E. Monroe, D.A. Elias, L. Pasa-Tolic, G.A. Anderson, and D.J. Anderson, et al. 2006. "AMT Tag Approach to Proteomic Characterization of Deinococcus Radiodurans and Shewanella Oneidensis." In Microbial Proteomics, Methods of Biochemical Analysis, edited by I. Humphery-Smith and M. Hecker. 113-134. Hoboken, New Jersey:John Wiley & Sons, Inc. PNNL-SA-42692.

2005

Masselon C.D., L. Pasa-Tolic, N. Tolic, G.A. Anderson, B. Bogdanov, A.N. Vilkov, and Y. Shen, et al. 2005. "Targeted Comparative Proteomics by Liquid Chromatography - Tandem Fourier ion cyclotron resonance Mass Spectrometry." Analytical Chemistry 77, no. 2:400-406. PNNL-SA-42470.

Shen Y., J. Kim, E.F. Strittmatter, J.M. Jacobs, D.G. Camp, R. Fang, and N. Tolic, et al. 2005. "Characterization of the human blood plasma proteome." Proteomics 5, no. 15:4034-4045. PNWD-SA-6708.

2004

Shen Y., N. Tolic, C.D. Masselon, L. Pasa-Tolic, D.G. Camp, G.A. Anderson, and R.D. Smith, et al. 2004. "Nanoscale Proteomics." Analytical and Bioanalytical Chemistry 378, no. 4:1037-1045. PNNL-SA-39154.

Shen Y., N. Tolic, C.D. Masselon, L. Pasa-Tolic, D.G. Camp, K.K. Hixson, and R. Zhao, et al. 2004. "Ultrasensitive Proteomics using High-Efficiency on-Line Micro-SPE-NanoLC-NanoESI MS and MS/MS." Analytical Chemistry 76, no. 1:144-154. PNNL-SA-38244.

2003

Mohan D., L. Pasa-Tolic, C.D. Masselon, N. Tolic, B. Bogdanov, K.K. Hixson, and R.D. Smith, et al. 2003. "Integration of Electrokinetic-Based Multidimensional Separations/Concentration Platform with electrospray ionization-Fourier transform ion cyclotron resonance-mass spectrometry for Proteome Analysis of Shewanella Oneidensis." Analytical Chemistry 75, no. 17:4432-4440. PNNL-SA-39340.

2002

Berger S.J., S. Lee, G.A. Anderson, L. Pasa-Tolic, N. Tolic, Y. Shen, and R. Zhao, et al. 2002. "High-Throughput Global Peptide Proteomic Analysis by Combining Stable Isotope Amino Acid Labeling and Data-Dependent Multiplexed-MS/MS." Analytical Chemistry 74, no. 19:4994-5000. PNNL-SA-39339.

Lipton M.S., L. Pasa-Tolic, G.A. Anderson, D.J. Anderson, D.L. Auberry, J.R. Battista, and M.J. Daly, et al. 2002. "Global Analysis of Deinococcus Radiodurans Proteome by Csing Accurate Mass Tags." Proceedings of the National Academy of Sciences of the United States of America 99, no. 17:11049-11054. PNNL-SA-35211.

Pasa-Tolic L., M.S. Lipton, C.D. Masselon, G.A. Anderson, Y. Shen, N. Tolic, and R.D. Smith. 2002. "Gene expression profiling using advanced mass spectrometric approaches." Journal of Mass Spectrometry 37, no. 12:1185-1198. PNWD-SA-5864.

Pasa-Tolic L., R. Harkewicz, G.A. Anderson, N. Tolic, Y. Shen, R. Zhao, and B.D. Thrall, et al. 2002. "Increased Proteome Coverage for Quantitative Peptide Abundance Measurements Based upon High Performance Separations and DREAMS FTICR Mass Spectrometry." Journal of the American Society for Mass Spectrometry 13, no. 8:954-963. PNNL-SA-35815.

2001

Belov M.E., G.A. Anderson, N.H. Angell, Y. Shen, N. Tolic, H.R. Udseth, and R.D. Smith. 2001. "Dynamic Range Expansion Applied to Mass Spectrometry (DREAMS) Based on Data-Dependent Selective Ion Ejection in Capillary Liquid Chromatography Fourier Transform Ion Cyclotron Resonance for Enhanced Proteome Characterization." Analytical Chemistry 73, no. 21:5052-5060. PNNL-SA-35028.

Li L., C.D. Masselon, G.A. Anderson, L. Pasa-Tolic, S. Lee, Y. Shen, and R. Zhao, et al. 2001. "High-Throughput Peptide Identification from Protein Digests Using Data-Dependent Multiplexed Tandem FTICR Mass Spectrometry Coupled with Capillary Liquid Chromatography." Analytical Chemistry 73, no. 14:3312-3322. PNWD-SA-5251.

Shen Y., N. Tolic, R. Zhao, L. Pasa-Tolic, L. Li, S.J. Berger, and R. Harkewicz, et al. 2001. "High-Throughput Proteomics Using High Efficiency Multiple-Capillary Liquid Chromatography With On-Line High-Performance ESI FTICR Mass Spectrometry." Analytical Chemistry 73, no. 13:3011-3021. PNNL-SA-33921.

2000

Jensen P.K., L. Pasa-Tolic, K.K. Peden, S. Martinovic, M.S. Lipton, G.A. Anderson, and N. Tolic, et al. 2000. "Mass Spectrometric Detection for Capillary Isoelectric Focusing Separations of Complex Protein Mixtures." Electrophoresis 21, no. 7:1372-1380. PNNL-SA-32088.

1999

Pasa-Tolic L., P.K. Jensen, G.A. Anderson, M.S. Lipton, K.K. Peden, S. Martinovic, and N. Tolic, et al. 1999. "High Throughput Proteome-Wide Precision Measurements of Protein Expression using Mass Spectrometry." Journal of the American Chemical Society 121, no. 34:7949-7950. PNNL-SA-31133.