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Brenda Bass

Institution
University of Utah
ORCID
ORCID logo 0000-0003-1728-2254

Projects

Mechanism of siRNA processing by the Dicer-2:R2D2 complex

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The Dicer-2 RNA processing enzyme in invertebrates plays dual roles in processing endogenous and viral siRNAs using distinct mechanisms. We previously determined a 6.8 Å structure of Drosophila Dicer…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Mechanism of RNA processing by the Dicer enzyme

Lead Institution
University of Utah
Principal Investigator
Peter Shen
We aim to achieve an atomic-resolution understanding of how Dicer recognizes and processes its RNA substrates. We recently solved a 6.8 Å resolution cryo-EM structure of the Drosophila Dicer-2 (dmDcr…