Chenghong Lei

Characterization of protein confinement in functionalized nanoporous supports

Lead Institution

Guilin University of Technology

Principal Investigator

Chenghong Lei

Project type

Large-Scale EMSL Research

One of the key fundamental scientific questions is how isolated proteins maintain their native active conformations in solution or in immobilization matrix. Molecular crowding and confinement theory…

Measurement and Optimization of the Redox Properties of Enzymes Using Single-Molecule Imaging, Controlled Electrochemical Potential, and Nanoscale Confinement

Lead Institution

Western University of Health Sciences

Principal Investigator

Thomas Squier

Project type

Large-Scale EMSL Research

We propose a new multi-disciplinary approach to single-molecule spectroscopy to image the redox kinetics of enzymes in spatially confined geometries under controlled electrochemical potential. We…

Computer Simulations of Protein-Nanomaterial Interactions

Lead Institution

Universidade Federal de Pernambuco

Principal Investigator

Roberto Lins Neto

Project type

Capability Research

The development of nanotechnology has led to an increasing interest in interfacing biological molecules with nanomaterials. Proteins have been used to functionalize nanomaterials controlling their…

Enzymatic Single-Molecule Spectroelectrochemistry by Nanoscale Confinement and Nanometer Scale Super Resolution Fluorescence Imaging

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Dehong Hu

We propose a new multi-disciplinary approach via single-molecule spectroscopy to study enzyme-catalyzed single-molecule electron transfer reaction and image the redox kinetics of enzymes in nanometer…

Characterization of Surface and Materials

Lead Institution

Guilin University of Technology

Principal Investigator

Chenghong Lei

Project type

Capability Research

Surface characterization Bio materials characterization Nano materials characterization

Single-Molecule and Single-Particle Spectroelectrochemistry by Super- Resolution Fluorescence Imaging

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Dehong Hu

In chemical and biological systems, interfacial redox processes play important roles. Redox reactions are ubiquitous in biological systems, from metabolism and nutrient utilization from the…

EMSL Science Overview

Chenghong Lei

Projects

Characterization of protein confinement in functionalized nanoporous supports

Measurement and Optimization of the Redox Properties of Enzymes Using Single-Molecule Imaging, Controlled Electrochemical Potential, and Nanoscale Confinement

Computer Simulations of Protein-Nanomaterial Interactions

Enzymatic Single-Molecule Spectroelectrochemistry by Nanoscale Confinement and Nanometer Scale Super Resolution Fluorescence Imaging

Characterization of Surface and Materials

Single-Molecule and Single-Particle Spectroelectrochemistry by Super- Resolution Fluorescence Imaging