David Eisenberg

University of California, Los Angeles

0000-0003-2432-5419

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structure determination of full-length amyloid fibrils of protein tau seeded by fibrils extracted from brains of Alzheimer’s Disease (AD) patients

Lead Institution

University of California, Los Angeles

Principal Investigator

David Eisenberg

The accumulation of amyloid fibrils in the brain is associated with physiological events that trigger cascades of numerous neurodegenerative diseases. Here, we aim to use cryo-EM to determine the…

Structure determination of transthyretin amyloid fibrils extracted from amyloidosis patients

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Lorena Saelices

Here, we aim to use cryo-electron microscopy to determine the structures of full-length transthyretin fibrils extracted from autopsied or explanted hearts from ATTR patients carrying either a wild…