David Sabatini

Whitehead Institute

0000-0002-1446-7256

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Conformational changes in Rag GTPases orchestrate signaling activities of mTORC1

Lead Institution

Whitehead Institute

Principal Investigator

David Sabatini

The mTORC1 protein kinase is a growth regulator that responds to stimuli, including nutrients and growth factors. Amino acids promote its translocation to the lysosomal surface, where it interacts…