Dhakaram Pangeni Sharma

Florida State University

0000-0002-5938-8770

Projects

Determination of the structure of an archaeal clamp loading complex
via single particle cryogenic electron microscopy

Lead Institution

Florida State University

Principal Investigator

Zucai Suo

Replicative DNA polymerases associate with ring-shaped sliding clamps that encompass the DNA and therefore allow processive DNA synthesis. Loading of the clamp requires a clamp loading complex that…

Structural investigation of DNA polymerase switching during translesion DNA synthesis

Lead Institution

Florida State University

Principal Investigator

Zucai Suo

DNA lesions are frequently introduced throughout genomes by a variety of biological and environmental agents. When encountered, these lesions can stall DNA replication machinery and the stalling can…