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Diana Bigelow

Institution
Pacific Northwest National Laboratory

Projects

Global and Targeted Proteomic Identification of oxidative modifications.

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Diana Bigelow
Project type
Exploratory Research
Recent research has provided an emerging picture of the significant role of reactive oxygen/nitrogen species (ROS/RNS) and their associated modification of cellular proteins in cellular signaling…

Role of Confinement and Material Surface on Protein Dynamics and Function

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Limited Scope
Our goal is to develop a mechanistic understanding of optimal material properties that would permit the functional stabilization of broad classes of proteins with utility to a range of detection and…

Role of Confinement and Material Surface on Protein Dynamics and Function

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Kathleen McAteer
Project type
Limited Scope
Our goal is to develop a mechanistic understanding of optimal material properties that would permit the functional stabilization of broad classes of proteins with utility to a range of detection and…

Proteomics of Membrane Protein Complexes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Diana Bigelow
Project type
Exploratory Research
A comprehensive understanding of the effects of cellular stress on calcium signaling requires correlated measurements of intracellular calcium transients and global proteomic analysis of both calcium…