Eric Ackerman

MRI imaging and NMR/confocal mimaging of Xenopus germ cells and early embryos

Lead Institution

Sandia National Laboratory

Principal Investigator

Eric Ackerman

Project type

Capability Research

We seek to understand how cells respond to environmental stresses by non-invasive, non-destructive methods. The combination of MRI imaging with some of the largest known cells provides unique…

Identification of order and disorder in protein XPA

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lilia Lakoucheva

Project type

Exploratory Research

The DNA repair protein Xeroderma pigmentosum group A (XPA) is a crucial component of the nucleotide excision repair pathway. The structure of full-length XPA has proved intractable by both NMR and X…

Conceptual Animations of Efficient Enzymes within Functionalized Mesoporous Silica

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Michael Perkins

Project type

Exploratory Research

These conceptual animations will illustrate how enzymes when held in functionalized mesoporous silica (FMS) become highly efficient catalysts. The process of using FMS for re-energizing inactive…

Measurement and Optimization of the Redox Properties of Enzymes Using Single-Molecule Imaging, Controlled Electrochemical Potential, and Nanoscale Confinement

Lead Institution

Western University of Health Sciences

Principal Investigator

Thomas Squier

Project type

Large-Scale EMSL Research

We propose a new multi-disciplinary approach to single-molecule spectroscopy to image the redox kinetics of enzymes in spatially confined geometries under controlled electrochemical potential. We…

Fluorescence measurements of recombinant proteins

Lead Institution

Sandia National Laboratory

Principal Investigator

Eric Ackerman

Project type

Exploratory Research

EMSL Science Overview

Eric Ackerman

Projects

MRI imaging and NMR/confocal mimaging of Xenopus germ cells and early embryos

Identification of order and disorder in protein XPA

Conceptual Animations of Efficient Enzymes within Functionalized Mesoporous Silica

Measurement and Optimization of the Redox Properties of Enzymes Using Single-Molecule Imaging, Controlled Electrochemical Potential, and Nanoscale Confinement

Fluorescence measurements of recombinant proteins