Eric Ortlund

Emory University

0000-0001-8855-3029

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structural studies of full-length thioesterase superfamily member 1

Lead Institution

Emory University

Principal Investigator

Eric Ortlund

Thioesterase superfamily member 1 (Them1) suppresses thermogenesis in brown adipose tissue through hydrolyzing acyl-CoA destined for beta-oxidation. Ablation of Them1 in mice increases energy…

Imaging Transcriptional Complexes by CryoEM

Lead Institution

Emory University

Principal Investigator

Eric Ortlund

Nuclear receptors (NRs) sense changes in lipid metabolite levels to trigger specific patterns of gene regulation, which drive critical biological processes including metabolism, development, and…