Jaime Jensen

Vanderbilt University Medical Center

0000-0002-8818-7513

Projects

Cryo-EM Analysis of TcdB in Complex with Host Cell Receptors

Lead Institution

Vanderbilt University Medical Center

Principal Investigator

Dana Lacy

Clostridioides difficile infection (CDI) is responsible for the majority of hospital acquired diarrhea cases reported in the United States. The pathology of CDI relies on the activity of three…

Cryo-EM analysis of the C. perfringens toxin TpeL with its host cell receptor LRP1

Lead Institution

Vanderbilt University Medical Center

Principal Investigator

Dana Lacy

Clostridioides difficile infection is often activated by alterations in the gut microbiota through antibiotic use, and recurrent infections are associated with severe clinical outcomes. Pathogenesis…