James Fraser

University of California, San Francisco

0000-0002-5080-2859

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Synthesis and rational design of next-generation ribosome-targeting inhibitors

Lead Institution

University of California, San Francisco

Principal Investigator

James Fraser

Antibiotic resistance is an urgent threat to public health. CryoEM of the bacterial ribosome affords insight into the interactions between organic inhibitor scaffolds, the RNA, and even the nascent…