Jean-Paul Armache

Visualizing stimulated chromatin regulatory proteins bound to substrate

Lead Institution

New York University School of Medicine

Principal Investigator

Karim Armache

The regulation of gene activity is a key regulatory process during cellular differentiation and is a crucial requirement for development in multicellular organisms. A large number of mechanisms have…

Structural studies of chromatin complexes involved in human diseases

Lead Institution

Pennsylvania State University

Principal Investigator

Song Tan

The nucleosome is a fundamental unit of chromatin and the target of a host of gene regulatory chromatin enzymes and proteins. It consists of DNA wrapped around a protein core, composed of histones…

Understanding the mechanisms of DNA damage repair in the nucleosomal context

Lead Institution

Pennsylvania State University

Principal Investigator

Jean-Paul Armache

Many human diseases, such as cancer, neuropathies, and others result from DNA damage. Estimates suggest that an average human cell sustains tens of thousands of lesions each per day. With ~10^13…

EMSL Science Overview

Jean-Paul Armache

Projects

Visualizing stimulated chromatin regulatory proteins bound to substrate

Structural studies of chromatin complexes involved in human diseases

Understanding the mechanisms of DNA damage repair in the nucleosomal context