Jessica Lukowski

Spatial Metabolomics for Human Kidneys

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity and mortality in patients in the US. However, we lack a clear understanding of the major…

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil mesocosms

Lead Institution

University of Massachusetts Medical School

Principal Investigator

Elizabeth Shank

Soil microbial processes exert a major influence on many of our planet's ecosystems, yet our ability to directly observe the enzymatic and metabolic activities of microbes within soil is…

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Tissue-scale or cell-population-level analysis (i.e., ‘bulk analysis’) yields averaged abundance data that can mask critical information about the state of individual cells. Through a recently ended…

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil mesocosms

Lead Institution

University of Massachusetts Medical School

Principal Investigator

Elizabeth Shank

Soil microbial processes exert a major influence on many of our planet's ecosystems, yet our ability to directly observe the enzymatic and metabolic activities of microbes within soil is…

Spatial Metabolomics and Glycomics for Human Kidneys

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Acute kidney injury (AKI) and chronic kidney disease (CKD) are major contributors to overall morbidity and mortality in patients in the US. However, we lack a clear understanding of the major…

Iron, Ferroptosis and Ovarian Cancer

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

The goal of this proposal is to provide mechanistic information on the role of iron in ferroptosis, test how manipulating pathways of iron and lipid metabolism impact ferroptosis, and explore how…

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil microcosms

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Soil microbial processes exert a major influence on many of our planet's ecosystems, yet our ability to directly observe the enzymatic and metabolic activities of microbes within soil is…

EMSL Science Overview

Jessica Lukowski

Projects

Spatial Metabolomics for Human Kidneys

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil mesocosms

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil mesocosms

Spatial Metabolomics and Glycomics for Human Kidneys

Iron, Ferroptosis and Ovarian Cancer

Development and implementation of an in situ high-resolution isotopic microscope for measuring metabolic interactions in soil microcosms