Jianbin Ruan

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Mechanistic elucidation of inflammasome biology

Lead Institution

Boston Children's Hospital

Principal Investigator

Hao Wu

Innate immunity comprises ancient and evolutionarily conserved biological pathways that are imperative for the recognition of pathogens and endogenous damage. One such major signaling pathway…

Structural and mechanistic elucidation of non-canonical inflammasome signaling

Lead Institution

University of Connecticut

Principal Investigator

Jianbin Ruan

Caspase-4/-5/-11 non-canonical inflammasomes have been known to play pivotal roles in various inflammatory and infectious diseases, such as sepsis. Current studies demonstrate that caspase-4/-5/-11…

EMSL Science Overview

Jianbin Ruan

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Mechanistic elucidation of inflammasome biology

Structural and mechanistic elucidation of non-canonical inflammasome signaling