Nagesh Peddada

University of Texas Southwestern Medical Center

0000-0003-4033-7305

Projects

Visualizing a dynamically tethered DEAD-box ATPase-rRNA complex during ribosome maturation-

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Jan Erzberger

The assembly of ribosomes is a critical process in cells, and its dysregulation contributes to a range of human diseases termed ribosomopathies. Ribosome maturation relies on numerous enzymes, most…

Cryo-EM studies of trapped nuclear 60S ribosome biogenesis intermediates

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Jan Erzberger

We have genetically engineered yeast strain to trap distinct intermediates in the large ribosomal subunit maturation pathway. Single particle reconstructions of these particles reveal the function of…