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Cryo-EM studies of trapped nuclear 60S ribosome biogenesis intermediates


EMSL Project ID
51585

Abstract

We have genetically engineered yeast strain to trap distinct intermediates in the large ribosomal subunit maturation pathway. Single particle reconstructions of these particles reveal the function of large macromolecular complexes in regulating the rearrangement of rRNA elements within nuclear 60S particles.

Project Details

Start Date
2020-07-15
End Date
2021-03-17
Status
Closed

Team

Principal Investigator

Jan Erzberger
Institution
University of Texas Southwestern Medical Center

Team Members

Nagesh Peddada
Institution
University of Texas Southwestern Medical Center