Nicholas Schnicker

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Determination of RAD52 and replication fork DNA complex

Lead Institution

University of Iowa

Principal Investigator

Maria Spies

RAD52 is an emerging target for drug discovery targeting DNA repair-deficient tumors. The exact cellular functions and structural mechanisms of RAD52, however, remain unresolved. This proposed…

Mechanisms of DNA damage access within the nucleosome during Base Excision Repair

Lead Institution

University of Kansas Medical Center

Principal Investigator

Bret Freudenthal

Despite the packaging of eukaryotic DNA into chromatin through repeating units known as the nucleosomes, it is constantly damaged via reactive oxygen species (ROS). 8oxo-guanine (8oxoG) is a common…

EMSL Science Overview

Nicholas Schnicker

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Determination of RAD52 and replication fork DNA complex

Mechanisms of DNA damage access within the nucleosome during Base Excision Repair