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Peter Shen

Institution
University of Utah
ORCID
ORCID logo 0000-0002-6256-6910

Projects

Mechanism of siRNA processing by the Dicer-2:R2D2 complex

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The Dicer-2 RNA processing enzyme in invertebrates plays dual roles in processing endogenous and viral siRNAs using distinct mechanisms. We previously determined a 6.8 Å structure of Drosophila Dicer…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structure of the RPE65-CCT folding intermediate

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The retinal pigment epithelium 65 kDa protein (RPE65) plays an essential role in human vision by catalyzing the conversion of all-trans retinol esters to 11-cis retinol. This reaction is a key step…

Mechanism of RNA processing by the Dicer enzyme

Lead Institution
University of Utah
Principal Investigator
Peter Shen
We aim to achieve an atomic-resolution understanding of how Dicer recognizes and processes its RNA substrates. We recently solved a 6.8 Å resolution cryo-EM structure of the Drosophila Dicer-2 (dmDcr…

Structure and function of the Gbeta5-CCT complex

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The cytosolic chaperonin CCT is a large, 1 MDa protein folding machine that plays a central role in maintaining the cellular proteome. CCT contributes to proteome homeostasis by assisting in the…

Structure and function of the Gbeta5-CCT complex

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The cytosolic chaperonin CCT is a large, 1 MDa protein folding machine that plays a central role in maintaining the cellular proteome. CCT contributes to proteome homeostasis by assisting in the…

Structure and function of the VCP/p47 complex

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The VCP AAA+ ATPase is a key component of the ubiquitin-proteasome system and is best characterized for its role in unfolding ubiquitylated proteins prior to their degradation. VCP is also involved…