Po-Lin Chiu

Cryo-EM Structural Study of the Polymerase Zeta Complex with Its Cofactors

Lead Institution

Mayo Clinic

Principal Investigator

Rajiv Kumar

Cellular DNA is damaged in the course of normal cellular metabolic activities and by environmental factors such as chemicals and ultraviolet light that can cause DNA lesions. This DNA lesion damage…

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Cryo-EM of the disease mutant p97 bound with its cofactor p47

Lead Institution

Arizona State University

Principal Investigator

Po-Lin Chiu

Mutation in p97/VCP (valosin-containing protein), an ATPase associated with diverse cellular activities, has been implicated in IBMPFD/ALS, which currently does not have an effective medical…

EMSL Science Overview

Po-Lin Chiu

Projects

Cryo-EM Structural Study of the Polymerase Zeta Complex with Its Cofactors

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Cryo-EM of the disease mutant p97 bound with its cofactor p47