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Ponni Rajagopal

Institution
University of Washington

Projects

NMR Structural Investigations of BRCA1

Lead Institution
University of Washington
Principal Investigator
Rachel Klevit
Project type
Capability Research
The breast and ovarian cancer tumor suppressor protein, BRCA1, supports a number of fundamental cellular processes. Its absence during embryogenesis is lethal. Loss of function in proliferating…

Structure and Dynamics of aB57.

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
alphaB-crystallin (aB) is the basic B-subunit of alpha-crystallin, a lenticular protein that is essential for maintaining eye-lens transparency. aB is found associated with a variety of neuro…

alphaB-crystallin - the core and the Oligomer : A Structural Investigation

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
alphaB-crystallin (alphaB) belongs to the family of small heat shock proteins (sHSPs) and has been shown in vitro to be a molecular chaperone. It is one of the proteins essential for maintaining eye…

Structural Investigation of a Molecular Chaperone

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
?B-Crystallin (?B) belongs to the family of small heat shock proteins (sHSPs) and has been shown in vitro to be a molecular chaperone. It is one of the proteins essential for maintaining eye-lens…

Structural Investigation of alphaB-Crystallin Core Domains

Lead Institution
University of Washington
Principal Investigator
Ponni Rajagopal
Project type
Capability Research
Small Heat Shock Proteins (sHSPs) are ubiquitous cellular proteins that are over-expressed under conditions of stress in various organisms from bacteria to humans. ?B-Crystallin (?B), considered the…