Rajendra Joshi

Yarrowia lipolytica for biotechnology and synthetic biology

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Erin Bredeweg

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics/metabolomics to establish baseline cell biological and metabolite data on DNA agility in eukaryotic organisms, and…

Developing KBase-NWChem workflow for integrating molecular properties with Genome-Scale Metabolic Modeling

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Neeraj Kumar

One of the challenges to investigate natural and engineered biological systems at molecular-level is to accurately predict chemical properties of thousands of metabolites involved in cell metabolism…

Multiscale Modeling of Complex Metabolic and Regulatory Networks of Yarrowia lipolytica

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Neeraj Kumar

Modifying genetic and metabolic pathways in microbes/plants to design systems with desired function remains challenging. Our inability to anticipate how the host organism will respond is due to the…

COVID-19: Molecular design and analysis to inform small molecule therapeutics related to COVID-19

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Neeraj Kumar

The multi-laboratory project will apply DOE capabilities to complement resources available in the public and private sector and thereby accelerate discovery of medical therapeutics targeting SARS-COV…

EMSL Science Overview

Rajendra Joshi

Projects

Yarrowia lipolytica for biotechnology and synthetic biology

Developing KBase-NWChem workflow for integrating molecular properties with Genome-Scale Metabolic Modeling

Multiscale Modeling of Complex Metabolic and Regulatory Networks of Yarrowia lipolytica

COVID-19: Molecular design and analysis to inform small molecule therapeutics related to COVID-19