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Sarah Clark

Institution
Oregon Health & Science University

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Architecture of native protocadherin-15 in complex with LHFPL5

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Mechanotransduction machinery located at the tips of hair bundles in the inner ear are responsible for our sensations of movement and sound. Each bundle is composed of stereocilia that are connected…

Elucidating the structure of C. elegans TMC1 and TMC2

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Transmembrane channel-like (TMC) proteins are a unique family of channel-like proteins that are conserved from humans to C. elegans. Vertebrates express eight isoforms, two of which are essential for…