Sean Mulligan

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Understanding the structural basis of RFX complex in regulating MHC gene expression

Lead Institution

Oregon Health & Science University

Principal Investigator

Liman Zhang

The Major Histocompatibility complex (MHC) is critical in immune system for T cell maturation and self vs nonself discrimination, thus expression of MHC genes has to be tightly regulated. Active…

Structural study of full-length SARS-Cov-2 Spike proteins by Cryo-EM

Lead Institution

Oregon Health & Science University

Principal Investigator

Liman Zhang

As of February 25th, 2020 there were 80,146 confirmed cases of SARS-Cov-2 infection across the globe. However, no vaccine or drug is available to prevent or treat the infection. Spike protein of SARS…

Structural characterization of protozoa Hsp100 by single-particle cryo-transmission electron microscopy (Cryo-TEM).

Lead Institution

Sao Carlos Institute of Chemistry, University of São Paulo

Principal Investigator

Julio Borges

Chaperones, such as Hsp100, can help maintain cellular homeostasis and adaptation playing an important role for different organisms. The Hsp100 has a disaggregase action, acting with other proteins…

EMSL Science Overview

Sean Mulligan

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Understanding the structural basis of RFX complex in regulating MHC gene expression

Structural study of full-length SARS-Cov-2 Spike proteins by Cryo-EM

Structural characterization of protozoa Hsp100 by single-particle cryo-transmission electron microscopy (Cryo-TEM).