Shasha Shi

University of Colorado Anschutz Medical Campus

0000-0002-2295-509x

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Determine the structural basis of splicing modulation by small molecules

Lead Institution

University of Colorado Anschutz Medical Campus

Principal Investigator

Rui Zhao

Aberrant pre-mRNA splicing contributes to 10-15 % of genetic disorders, including Spinal Muscular Atrophy (SMA). SMA is a potentially lethal neurodegenerative disorder caused by loss of function…