Sun Hur

Boston Children's Hospital

0000-0001-5005-5550

Projects

Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

PNNL will create and operate the Pacific Northwest Center for Cryo-EM (PNCC), a state-of-the-art national center for cryo-electron microscopy (Cryo-EM) that will rapidly and efficiently collect and…

Structural insights into the regulation of MDA5-mediated antiviral signaling activity

Lead Institution

Boston Children's Hospital

Principal Investigator

Sun Hur

Effective antiviral immunity involves the recognition of viral dsRNA by the innate immune receptor MDA5 and the subsequent interferon signaling cascade. Aberrant recognition of endogenous “self” RNAs…