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Thomas Leeper

Institution
University of Washington

Projects

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationships of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationships of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationship of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationship of human telomerase, the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini …

Assembly of the mRNA 3'-end processing machinery

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Large-Scale EMSL Research
We propose to use NMR to study the structural basis for the assembly of the protein complex responsible for the formation of mature 3'-ends of mRNAs by cleavage and polyadenylation, and the…

Structure of Human Telomerase RNA

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Significance - Telomerase is a ribonucleoprotein responsible for the replication of the chromosome termini. It is composed of a RNA of 400 nucleotides and several proteins that carry out the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). It is composed of an RNA (of 400 nucleotides in vertebrates)…

Structure of Telomerase RNA

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). It is composed of a RNA and several proteins. The RNA is a…

Structure of telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). Since telomerase is selectively activated in most human…