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Structure of Telomerase RNA


EMSL Project ID
3253

Abstract

Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). It is composed of a RNA and several proteins. The RNA is a landing pad to allow protein binding, but it also performs essential functions in regulating the enzyme. There are no structures from NMR or crystallography for any of the protein components or of the essential domains of its RNA. This is a critical limit in efforts directed at addressing the biological function of this enzyme. We aim to bridge this gap by pursuing the structural biology of this RNA-protein complex, specifically by studying protein-RNA interactions derived from telomerase using NMR.

Project Details

Project type
Capability Research
Start Date
2003-07-01
End Date
2004-07-14
Status
Closed

Team

Principal Investigator

Gabriele Varani
Institution
University of Washington

Team Members

Thomas Leeper
Institution
University of Washington