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Gabriele Varani

Institution
University of Washington

Projects

Structure of Telomerase RNA

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). It is composed of a RNA and several proteins. The RNA is a…

Assembly of the mRNA 3'-end processing machinery

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Large-Scale EMSL Research
We propose to use NMR to study the structural basis for the assembly of the protein complex responsible for the formation of mature 3'-ends of mRNAs by cleavage and polyadenylation, and the…

Structure of telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). Since telomerase is selectively activated in most human…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationships of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationships of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationship of human telomerase. Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
We are using NMR to study the structure/function relationship of human telomerase, the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini …

Structure of Designer Proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Protein design is one of the great challenges of modern molecular biology, promising to provide entirely new biological activities together with an unprecedented understanding of protein structure…

Assembly of the mRNA 3'-end processing machinery

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Large-Scale EMSL Research
We propose to use NMR to study the structural basis for the assembly of the protein complex responsible for the formation of mature 3'-ends of mRNAs by cleavage and polyadenylation, and the…

Structure of Human Telomerase RNA

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Significance - Telomerase is a ribonucleoprotein responsible for the replication of the chromosome termini. It is composed of a RNA of 400 nucleotides and several proteins that carry out the…

Structure of Telomerase RNA and telomeric proteins

Lead Institution
University of Washington
Principal Investigator
Gabriele Varani
Project type
Capability Research
Telomerase is the ribonucleoprotein (RNP) enzyme responsible in most eukaryotes for the replication of the chromosome termini (telomeres). It is composed of an RNA (of 400 nucleotides in vertebrates)…

Seattle Structural Genomics Center for Infectious Diseases

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Garry Buchko
Project type
Exploratory Research
The Seattle Structural Genomics Center for Infectious Disease (SSGCID) is a consortium of four institutions (Seattle Biomedical Research Institue (SBRI), deCODE biostructures, University of…