Yang Li

University of Texas Southwestern Medical Center

0000-0001-9601-4885

Projects

Nuclear export of phosphorylated proteins by Karyopherin MSN5

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Yuh Chook

MSN5 is the 142 kDa S. cerevisiae exportin, which exports many different protein cargoes from the nucleus to the cytoplasm in response to cellular environmental changes. Peptide signals in several…

Structural basis for SidJ-catalyzed polyglutamylation of the SidE all-in-one ubiquitin ligases

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Vincent Tagliabracci

Enzymes with a protein kinase fold transfer phosphate from ATP to substrates in a process known as phosphorylation. We have discovered that the Legionella meta-effector SidJ adopts a protein kinase…

Nuclear import of histone H2A-H2B and histone chaperone Nap1 by Kap114

Lead Institution

University of Texas Southwestern Medical Center

Principal Investigator

Yuh Chook

Core histones organize DNA in the nucleus. Histones are synthesized in the cytoplasm and are be transported by to the nucleus by Karyopherin nuclear transport receptors. In the cytoplasm, histones…