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Zheng Ruan

Institution
Van Andel Research Institute
ORCID
ORCID logo 0000-0002-4412-4916

Projects

Cryo-EM studies of human TRPM2 channel

Lead Institution
Van Andel Research Institute
Principal Investigator
Juan Du
TRPM2, a Ca2+-permeable, nonselective cation channel belonging to the melastatin subfamily of the TRP superfamily, acts as a major “warmth sensor” in the hypothalamus to regulate core body…

Structural Investigations of Human TRPM4

Lead Institution
Van Andel Research Institute
Principal Investigator
Wei Lu
The aim of this research is to complete the gating cycle of human TRPM4 by solving the structures at multiple functional states at high-resolution. The recently published TRPM4 structures by our lab…

Structural determination of CALHM channels

Lead Institution
Van Andel Research Institute
Principal Investigator
Wei Lu
The calcium homeostasis modulators (CALHMs) are one of the key ATP release channel families, consisting of three members, CALHM1, 2 and 3. They are voltage-dependent, extracellular,…