Cryo-EM studies of human TRPM2 channel
EMSL Project ID
51189
Abstract
TRPM2, a Ca2+-permeable, nonselective cation channel belonging to the melastatin subfamily of the TRP superfamily, acts as a major “warmth sensor” in the hypothalamus to regulate core body temperature. Its activation is linked to both Ca2+ entry across the plasma membrane and Ca2+ release from lysosomes. TRPM2 thus plays essential roles in numerous Ca2+-related physiological processes including immune response, insulin release and cell death, and its dysregulation in diseases such as bipolar disorder and Alzheimer’s disease. Our lab has published the first structures of zebrafish and human TRPM2 channels in the past year and we aim to further explore the gating mechanism and pharmacology of this important ion channel. Of note, there are very few TRPM2-specific drugs available.
Project Details
Start Date
2020-01-15
End Date
2021-03-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members