The use of novel proteomics in the plasma and tumor microenvironment for class prediction in human breast cancer
EMSL Project ID
14097
Abstract
Hypotheses: (1) The human plasma proteome changes in response to the surgical removal of human breast cancer. (2) There is a difference in the plasma proteome in patients with breast cancer compared to control patients without a diagnosis of cancer. (3) Patterns of plasma protein concentrations can predict the outcome of human breast cancer in patients following operative removal of disease.Specific Aims: Using high resolution liquid chromatography (LC) coupled with Fourier transform ion cyclotron resonance (FTICR) mass spectrometry, to determine patterns of plasma protein concentrations related to the presence and recurrence of human breast cancer.
A) Compare the plasma proteomes of pre- and post- resection in patients with invasive breast cancer to determine whether concentrations of plasma proteins are associated with the absence or presence of the cancer.
B) Compare patterns of plasma proteome in humans with breast cancer with control patients without cancer.
C) Analyze the relationship between plasma proteome, and stage and disease progression in patients with invasive breast cancer.
Project Details
Project type
Exploratory Research
Start Date
2005-05-17
End Date
2007-03-20
Status
Closed
Released Data Link
Team
Principal Investigator